Aneuploidy
Recent clinical, regulatory, research and industry developments relating to this disease.
Cytogenetic signatures favoring metastatic organotropism in colorectal cancer.
Aneuploidy and complex genomic rearrangements in cancer evolution.
DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 industry development reported.
Industry & MarketViewHide
- 2026-07-08Aneuploidy selects for the acquisition of driver genes in breast cancerAcquisition · Nature News
- 2026-07-08IndustryAneuploidy selects for the acquisition of driver genes in breast cancerAcquisition · Nature News
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Neoplasms2
- Aneuploidy1
- Benzamides1
- Brain Neoplasms1
- Carcinoma, Renal Cell1
- Cell Cycle Proteins1
- Chromosome Aberrations1
- Chromosome Duplication1
Leading journals3
- Nature communications4
- Nature cancer2
- Genome research1
Leading researchers8
- Ahn JS1
- Ahn MJ1
- Almeida LV1
- Antonarakis ES1
- Armstrong AJ1
- Baker TM1
- Bakouny Z1
- Bartholomeu DC1
Affiliations (unnormalised)6
- Memorial Sloan Kettering Cancer Center2
- The Francis Crick Institute2
- The University of Texas MD Anderson Cancer Center2
- Asklepios Hospital Harburg1
- Bellvitge Biomedical Research Institute (IDIBELL)1
- Center for Precision Environmental Health1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Aneuploidy is a chromosomal state in which cells have an abnormal number of chromosomes or chromosome fragments compared with the normal diploid complement. It includes losses or gains of whole chromosomes or chromosome pairs, such as monosomy, trisomy, nullisomy, and tetrasomy.
The supplied grounding does not identify specific causes of aneuploidy in general. In cancer, large genomic alterations can arise through mutational processes that produce copy number gains and losses, as well as more complex rearrangements.
Aneuploidy changes gene dosage by altering the number of chromosomes or chromosome fragments present in a cell. In tumors, large genomic alterations can affect the expression of many genes and influence cell fitness, contributing to tumor development and evolution.
AI-generated summary grounded in MeSH and 1 peer-reviewed source. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
The chromosomal constitution of cells which deviate from the normal by the addition or subtraction of CHROMOSOMES, chromosome pairs, or chromosome fragments. In a normally diploid cell (DIPLOIDY) the loss of a chromosome pair is termed nullisomy (symbol: 2N-2), the loss of a single chromosome is MONOSOMY (symbol: 2N-1), the addition of a chromosome pair is tetrasomy (symbol: 2N+2), the addition of a single chromosome is TRISOMY (symbol: 2N+1).
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.