Anorexia

The grounding supports anorexia as a symptom associated with acute infection and with cancer cachexia. It also notes that anorexia nervosa is the disorder for which anorexia is a defining characteristic, but it does not provide a specific cause for anorexia itself.

The literature grounding links anorexia to metabolic adaptation during acute infection, where reduced appetite may function as a sickness behaviour that influences immune response, inflammation, tissue stress, and pathogen fitness. It also appears in cancer cachexia, where anorexia is discussed alongside systemic inflammation, metabolic abnormalities, and wasting.

Acute infection is a supported context in which anorexia occurs. Cancer cachexia is another supported associated condition, but the grounding does not identify broader risk factors for anorexia itself.

Cannabinoid drugs are discussed in the grounding as being studied for appetite stimulation in HIV/AIDS, indicating use of cannabinoids as an appetite-stimulating modality. Beyond that drug-class level association, the supplied material does not support a general standard-of-care treatment for anorexia itself.