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Disease
Anterior Cruciate Ligament Injuries
Late-stage therapeutic developmentEmerging research
1
Publications
10
Clinical trials
2018
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Research2018-02-17Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 3 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
- Q1 2027Biologic Therapy to Prevent Osteoarthritis After ACL Injury
- Q3 2027Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control Trial
- Q4 2027Multi-Center Pilot Study to Evaluate Concentrated Bone Marrow Aspirate (cBMA) as a Treatment to Modify Post-Traumatic Osteoarthritis (PTOA) Following Revision Anterior Cruciate Ligament Reconstruction (ACLR)
Major developments
Upcoming trial readoutHigh impact
Results expected Q3 20272026-04-09
Major trial resultsHigh impact
Results posted2026-01-26
Clinical MilestonesViewHide
Results posted
Results expected
- 2026-04-09Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control TrialResults expected Q3 2027
- 2026-01-26Biologic Therapy to Prevent Osteoarthritis After ACL InjuryResults expected Q1 2027
- 2025-11-20Multi-Center Pilot Study to Evaluate Concentrated Bone Marrow Aspirate (cBMA) as a Treatment to Modify Post-Traumatic Osteoarthritis (PTOA) Following Revision Anterior Cruciate Ligament Reconstruction (ACLR)Results expected Q4 2027
Recently completed
Activity timeline5
- 2026-04-09ClinicalIntraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction: A Randomized Control TrialResults expected Q3 2027
- 2026-01-26ClinicalBiologic Therapy to Prevent Osteoarthritis After ACL InjuryResults expected Q1 2027
- 2026-01-26ClinicalGenicular Nerve Blocks for Arthroscopic Anterior Cruciate Knee Surgery: a Randomized Controlled TrialResults posted
- 2025-11-25ClinicalComparison of Preemptive Multimodal Analgesia and Femoral Triangle Block on Early Rehabilitation in ACL Reconstruction: A Prospective, Randomized, Double-Blind StudyPrimary completion
- 2025-11-20ClinicalMulti-Center Pilot Study to Evaluate Concentrated Bone Marrow Aspirate (cBMA) as a Treatment to Modify Post-Traumatic Osteoarthritis (PTOA) Following Revision Anterior Cruciate Ligament Reconstruction (ACLR)Results expected Q4 2027
Clinical trials
The current development programme across all trial phases.
Clinical programme
10
5
4
3
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes1
- Pediatrics1
Leading journals1
- Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA1
Leading researchers8
- Anderson A1
- Ardern CL1
- Chotel F1
- Cohen M1
- Ekås G1
- Engebretsen L1
- Feller JA1
- Forssblad M1
Affiliations (unnormalised)6
- Boston Children's Hospital1
- Centre Hospitalier Luxembourg1
- Children's Hospital of Philadelphia1
- College of Engineering1
- College of Science1
- FIFA Medical Center of Excellence1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Sprain or tear injuries to the ANTERIOR CRUCIATE LIGAMENT of the knee.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.