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Disease

Aortic Dissection

Late-stage therapeutic developmentEmerging research
MeSHAortic Dissection
2
Publications
12
Clinical trials
1
Related conditions
2019
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
  • 1 industry development reported.
Upcoming Milestones
Clinical Milestones7View
Results expected 4
Recently completed 3
Industry & Market1View
Activity timeline8

Clinical trials

8 sponsors · 2 new · 1 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
12
All trials
6
Active
3
Late-stage
4
Completed
Recruiting

Study on Ketorolac for Improving Outcomes and Prognosis in Patients With Stanford Type A Aortic Dissection -A Single-Center, Randomized, Double-Blind, Controlled Clinical Trial

Phase 3 · Recruiting · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

A Randomized, Double-blind, Placebo-controlled, Study to Identify the Opioid-sparing Effects, and Pain-reduction Potential of Low Dose Ketamine on Patients Undergoing TEVAR Procedures Receiving NCI

Phase 2 · Recruiting · Sam Tyagi

Creation of a Digital Twin for Predicting the Progression of Patients With Chronic Thoracic Aortic Dissection

N/A · Recruiting · Centre Hospitalier Universitaire Dijon

Protective Effect of Thymosin Α1 Against Negative Immune Dysregulation and Organ Dysfunction After Acute Aortic Dissection Surgery (PANDA II)

N/A · Recruiting · Nanjing Medical University

Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)

N/A · Recruiting · Nanjing Medical University

Changes in Antibacterial Therapy Based on Perioperative Dynamics of Presepsin During Reconstructive Thoracic Aorta Surgery

N/A · Recruiting · Petrovsky National Research Centre of Surgery
Recently completed

Efficacy of Nitric Oxide Administration for Reducing the Risk of Acute Kidney Injury in Patients With Acute Type A Aortic Dissection: a Randomized Controlled Trial

Phase 4 · Completed · Beijing Anzhen Hospital

Feasibility and Safety of Thrombosomes® on Time to Hemostasis in Patients Undergoing Emergency Surgery for Thoracic Aortic Dissections - a Randomized, Controlled, Open-label Investigator-initiated Pilot Trial

Phase 2 · Completed · Jakob Stensballe, MD, PhD

Assessment of the Efficacy of Glucocorticoids in Improving Post-operative Organ Dysfunction in Patients With Acute Type A Aortic Dissection(GLAD): a Randomized Controlled Trial

Phase 4 · Completed · Shanghai Zhongshan Hospital

Protective Effect of Ulinastatin Against Negative Inflammatory Response and Organ Dysfunction After Acute Type a Aortic Dissection Surgery (PANDA I)

N/A · Completed · Nanjing Medical University

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20142019
Major themes2
  • Aorta, Abdominal1
  • Aorta, Thoracic1
Leading journals1
  • European heart journal2
Leading researchers8
  • Aboyans V1
  • Allmen RS1
  • Bartolomeo RD1
  • Bluethmann SM1
  • Boileau C1
  • Bossone E1
  • Deng L1
  • Eggebrecht H1
Affiliations (unnormalised)6
  • Icahn School of Medicine at Mount Sinai1
  • Jacobi Medical Center1
  • Mayo Clinic1
  • National Institutes of Health1
  • Penn State Cancer Institute1
  • Penn State College of Medicine1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Atherosclerosis2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A tear in the inner layer of the AORTA leading to interstitial HEMORRHAGE, and splitting (dissecting) of the aortic TUNICA MEDIA layer. It typically begins with a tear in the TUNICA INTIMA layer.

Identifiers
MeSHAortic Dissection
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.