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Disease

Aortic valve calcification

Late-stage therapeutic development

Also known as aortic valve calcification (disease).

4
Clinical trials
6
Associated genes
2
Related proteins
Current focus
Mucin-4 biologyTherapeutic developmentInflammation & immunity

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2028.
Upcoming Milestones
Major developments
Upcoming trial readoutImportant
Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: First In Human Study (EMBARK Study)
Results expected Q1 20282026-06-26
Major clinical milestoneImportant
Does Colchicine Reduce Progression of Aortic Valve Stenosis?
Primary completion2025-12-22
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

3 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
4
All trials
3
Active
1
Late-stage
1
Completed
Late-stage studies

Does Colchicine Reduce Progression of Aortic Valve Stenosis?

Phase 3 · Active, not recruiting · Radboud University Medical Center

Associated genes

6 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

IL60.46PALMD0.32MUC40.29LLPH0.13ATP13A30.11TMEM440.08

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Interleukin-6via IL60.46Mucin-4via MUC40.29

Reference

Authoritative identity, definition & identifiers.

Synonyms

aortic valve calcification (disease)

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.