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Disease
Aortic Valve Insufficiency
Late-stage therapeutic developmentEmerging research
1
Publications
14
Clinical trials
2012
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Two-year outcomes after transcatheter or surgical aortic-valve replacement.
Research2012-03-26The New England journal of medicine
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
- Q4 2026Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic Valves
- Q2 2027A Study to Assess Safety and Effectiveness of the JenaValve Trilogy™ Transcatheter Heart Valve System Versus Surgical Valve Replacement in Patients With Aortic Regurgitation
- Q1 2029J-VALVE Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement for Patients With Aortic Regurgitation Therapy
Major developments
Upcoming trial readoutImportant
Results expected Q2 20272026-07-07
Major clinical milestoneImportant
Primary completion2026-08-01
Clinical MilestonesViewHide
Results expected
- 2026-07-07A Study to Assess Safety and Effectiveness of the JenaValve Trilogy™ Transcatheter Heart Valve System Versus Surgical Valve Replacement in Patients With Aortic RegurgitationResults expected Q2 2027
- 2026-03-10J-VALVE Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement for Patients With Aortic Regurgitation TherapyResults expected Q1 2029
- 2025-12-22Safety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic ValvesResults expected Q4 2026
Activity timeline4
- 2026-08-01ClinicalTranscatheter Aortic Valve Replacement Using the JenaValve TrilogyTM Heart Valve System for Clinically Significant Aortic Regurgitation in Patients With Left Ventricular Assist Devices (LVAD)Primary completion
- 2026-07-07ClinicalA Study to Assess Safety and Effectiveness of the JenaValve Trilogy™ Transcatheter Heart Valve System Versus Surgical Valve Replacement in Patients With Aortic RegurgitationResults expected Q2 2027
- 2026-03-10ClinicalJ-VALVE Transcatheter Aortic Valve Replacement Versus Surgical Aortic Valve Replacement for Patients With Aortic Regurgitation TherapyResults expected Q1 2029
- 2025-12-22ClinicalSafety and Effectiveness of Balloon-Expandable Bioprosthetic SAPIEN X4 Transcatheter Heart Valve in Failing Aortic Bioprosthetic ValvesResults expected Q4 2026
Clinical trials
The current development programme across all trial phases.
Clinical programme
14
6
3
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Recent publications
Major themes1
- Cardiac Catheterization1
Leading journals1
- The New England journal of medicine1
Leading researchers8
- Akin JJ1
- Anderson WN1
- Dewey TM1
- Douglas PS1
- Fischbein M1
- Fontana GP1
- Greason KL1
- Hahn RT1
Affiliations (unnormalised)1
- Columbia University Medical Center and New York Presbyterian Hospital1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Pathological condition characterized by the backflow of blood from the ASCENDING AORTA back into the LEFT VENTRICLE, leading to regurgitation. It is caused by diseases of the AORTIC VALVE or its surrounding tissue (aortic root).
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.