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Disease

Atrial Flutter

Late-stage therapeutic developmentEmerging research
MeSHAtrial Flutter
2
Publications
23
Clinical trials
1
Related conditions
12
Associated genes
4
Related proteins
2023
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 3 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Clinical Milestones11View all 11
Results expected 3
Recently completed 5
Other updates 2
+3 more in the activity timeline below
Activity timeline11

Clinical trials

17 sponsors · 0 new · 4 completed in the last 12 months (net -2)

The current development programme across all trial phases.

Clinical programme
23
All trials
6
Active
16
Late-stage
6
Completed
Late-stage studies

The Danish Non-vitamin K Antagonist Oral Anticoagulation Study. A Cluster Randomized Study Comparing Safety and Efficacy of Edoxaban, Apixaban, Rivaroxaban and Dabigatran for Oral Anticoagulation in Atrial Fibrillation (DANNOAC-AF).

Phase 4 · Active, not recruiting · Herlev and Gentofte Hospital

Pragmatic Evaluation of a Pentaspline Pulsed Field Ablation System to Treat Atrial Fibrillation and Related Arrhythmias

Phase 4 · Active, not recruiting · Vivek Reddy

Rationale and Design of Dabigatran for Mitral Stenosis Atrial Fibrillation Trial

Phase 4 · Active, not recruiting · The University of Hong Kong

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

Phase 4 · Active, not recruiting · Population Health Research Institute

Management of Anticoagulant Therapy Monitored by an Implantable Device With Telecardiology in Patients With Acute Coronary Syndrome Associated With de Novo Atrial Fibrillation Arrhythmia: A Prospective Multicenter Study

Phase 4 · Active, not recruiting · Centre Hospitalier de PAU

An Open Label, Multi-center Trial to Evaluate the Feasibility and Safety of Short-term Treatment With Subcutaneously Injected Certoparin (8000 U Anti-Xa Twice Daily) in Patients With Persistent Nonvalvular Atrial Fibrillation

Phase 3 · Completed · Novartis
Recently completed

Stellate Ganglion Blockade for the Prevention of Atrial Fibrillation After Cardiac Surgery: A Randomized Placebo-Controlled Trial

Phase 2/3 · Completed · Mayo Clinic

Escalated Single Platelet Inhibition for One Month Plus Direct Oral Anticoagulation in Patients With Atrial Fibrillation and acUte coRonary Syndrome Undergoing percutaneoUS Coronary Intervention

Phase 4 · Completed · Ludwig-Maximilians - University of Munich

Appropriate Duration of Anti-Platelet and Thrombotic Strategy After 12 Months in Patients With Atrial Fibrillation Treated With Drug Eluting Stents (ADAPT AF-DES)

Phase 4 · Completed · Yonsei University

Sacubitril Valsartan in Preventing the Recurrence of Atrial Fibrillation After Ablation in Elderly Hypertensive Patients With Atrial Fibrillation

Phase 4 · Completed · Shanghai Jiao Tong University School of Medicine

An Open Label, Multi-center Trial to Evaluate the Feasibility and Safety of Short-term Treatment With Subcutaneously Injected Certoparin (8000 U Anti-Xa Twice Daily) in Patients With Persistent Nonvalvular Atrial Fibrillation

Phase 3 · Completed · Novartis

A Comparison of the Effectiveness of Carvedilol Versus Metoprolol for Atrial Fibrillation Appearing After Off-Pump Coronary Bypass Surgery in the Carvedilol or Metoprolol Post-Revascularization Atrial Fibrillation Controlled Trial (COMPACT)

N/A · Completed · Ministry of Health, Labour and Welfare, Japan

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20212023
Major themes5
  • Catheter Ablation2
  • Atrial Fibrillation1
  • Atrial Flutter1
  • Cryosurgery1
  • Pulmonary Veins1
Leading journals2
  • Circulation1
  • The New England journal of medicine1
Leading researchers8
  • Adeliño R1
  • Amit G1
  • Andrade JG1
  • Angaran P1
  • Anic A1
  • Anselme F1
  • Arentz T1
  • Bennett M1
Affiliations (unnormalised)6
  • Alfried Krupp Hospital1
  • Asklepios Hospital St Georg1
  • Clinic for Electrophysiology1
  • Copenhagen University Hospital1
  • From Vancouver General Hospital (J.G.A.1
  • German Center for Cardiovascular Research (DZHK)1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

KCNH20.60HCN40.50ZFHX30.49TBX50.48PRRX10.48CAV10.45KCNJ50.45CASZ10.42CASQ20.42CEP680.42SH3PXD2A0.42AOPEP0.41

Disease biology

4 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Voltage-gated inwardly rectifying potassium channel KCNH2via KCNH20.60Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4via HCN40.50Intercellular adhesion molecule 1via ICAM10.30P2X purinoceptor 3via P2RX30.08

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Atrial Fibrillation2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).

Identifiers
MeSHAtrial Flutter
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.