Brain Edema
Recent clinical, regulatory, research and industry developments relating to this disease.
Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q3 2026.
Clinical MilestonesViewHide
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes1
- Heart Arrest1
Leading journals3
- AJNR. American journal of neuroradiology1
- Cell1
- Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism1
Leading researchers8
- Ahmed Z1
- Al-Jubair T1
- Almutiri S1
- Bartynski WS1
- Bill RM1
- Cerrato M1
- Cervo L1
- Clarke-Bland C1
Affiliations (unnormalised)6
- Clinical Neuroimmunology Unit1
- Cumming School of Medicine1
- Department of Emergency Medicine and Max Harry Weil Institute for Critical Care Research and Innovation1
- Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico1
- Harvard Medical School1
- Institute of Clinical Sciences1
Reference
Authoritative identity, definition & identifiers.
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.