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Disease

Bronchiolitis

Late-stage therapeutic developmentEmerging research
MeSHBronchiolitis
1
Publications
18
Clinical trials
1
Associated genes
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Clinical Milestones6View
Results expected 4
Other updates 2
Activity timeline6

Clinical trials

18 sponsors · 1 new · 0 completed in the last 12 months (net -1)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
16
Late-stage
6
Completed
Late-stage studies

Characterization of Bronchodilator Response in Children With Bronchiolitis Using Phenotypic and Genotypic Features

Phase 3 · Recruiting · Nemours Children's Clinic

A Phase 3, Open-label, Randomized, Standard of Care-controlled, Parallel Study Arm Study to Demonstrate Efficacy and Safety of ARINA-1 in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) Progression in Participants With a Bilateral Lung Transplant

Phase 3 · Recruiting · Renovion, Inc.

A Randomized Controlled Trial on the Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis in Children

Phase 3 · Recruiting · Combined Military Hospital, Pakistan

Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age: a Point-of-care Testing Guided Randomized, Double-blind, Placebo-controlled Trial

Phase 4 · Recruiting · University of Oulu

Azithromycin to Prevent Wheezing Following Severe RSV Bronchiolitis-II

Phase 2/3 · Completed · Washington University School of Medicine

A European Multi-center, Randomised, Double-blind Trial of Pirfenidone in Bronchiolitis-obliterans-syndrome Grade 1-3 in Lung Transplant Recipients

Phase 2/3 · Completed · Rigshospitalet, Denmark
Recruiting

Characterization of Bronchodilator Response in Children With Bronchiolitis Using Phenotypic and Genotypic Features

Phase 3 · Recruiting · Nemours Children's Clinic

A Phase 3, Open-label, Randomized, Standard of Care-controlled, Parallel Study Arm Study to Demonstrate Efficacy and Safety of ARINA-1 in the Prevention of Bronchiolitis Obliterans Syndrome (BOS) Progression in Participants With a Bilateral Lung Transplant

Phase 3 · Recruiting · Renovion, Inc.

A Randomized Controlled Trial on the Comparative Efficacy of Hypertonic Saline vs Adrenaline Nebulization in Acute Bronchiolitis in Children

Phase 3 · Recruiting · Combined Military Hospital, Pakistan

Oral Prednisolone for Acute Rhinovirus Induced Wheezing in Children Less Than 2 Years of Age: a Point-of-care Testing Guided Randomized, Double-blind, Placebo-controlled Trial

Phase 4 · Recruiting · University of Oulu

Exploratory Study of Airway Basal Stem Cells on Treatment of Pediatric Bronchiolitis Obliterans

Early Phase 1 · Recruiting · Regend Therapeutics
Recently completed

A Randomized Controlled Trial Comparing Epinephrine and Dexamethasone to Placebo in the Treatment of Infants With Bronchiolitis

Phase 3 · Completed · Children's Hospital of Eastern Ontario

Efficacy of Vitamin D Supplementation for Children With Bronchiolitis at Sohag University Hospital

Phase 2/3 · Completed · Sohag University

Evaluating the Efficacy of Nebulised 3% Hypertonic Saline for Acute Bronchiolitis in Infants: A Study at Can Tho Children's Hospital, 2022-2024

Phase 2/3 · Completed · Can Tho University of Medicine and Pharmacy

Azithromycin to Prevent Wheezing Following Severe RSV Bronchiolitis-II

Phase 2/3 · Completed · Washington University School of Medicine

A European Multi-center, Randomised, Double-blind Trial of Pirfenidone in Bronchiolitis-obliterans-syndrome Grade 1-3 in Lung Transplant Recipients

Phase 2/3 · Completed · Rigshospitalet, Denmark

Effect of Heliox on Infants With Respiratory Syncytial Virus Acute Bronchiolitis-A Revisit Study

Phase 3 · Completed · Wael Seliem

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes2
  • Bronchiolitis1
  • COVID-191
Leading journals1
  • JAMA network open1
Leading researchers2
  • Simões EAF1
  • Suss RJ1
Affiliations (unnormalised)2
  • Center for Global Health1
  • University of Colorado School of Medicine and Children's Hospital Colorado1

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

ZNF170.00

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Inflammation of the BRONCHIOLES.

Identifiers
MeSHBronchiolitis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.