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Disease

Cardiac amyloidosis

Late-stage therapeutic development
Also known as Amyloid heart disease, Amyloid heart muscle disease, Amyloidosis of heart, Senile cardiac amyloidosis+1 more

Amyloid heart disease, Amyloid heart muscle disease, Amyloidosis of heart, Senile cardiac amyloidosis, amyloid cardiomyopathy.

17
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
[64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy
Results expected Q1 20272026-07-21
Upcoming trial readoutHigh impact
Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis
Results expected Q4 20262026-07-06
Clinical Milestones8View
Results posted 1
Results expected 4
Recently completed 3
Activity timeline8

Clinical trials

12 sponsors · 3 new · 2 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme
17
All trials
5
Active
10
Late-stage
6
Completed
Late-stage studies

A Multicenter, Open-Label, Single Arm, Post-Marketing Clinical Study to Evaluate the Therapeutic Effects of Acoramidis Hydrochlorideon Cardiac Biomarkers and Current Clinical Features in Patients With Transthyretin-type Cardiac Amyloidosis: The CARE ATTR Study

Phase 4 · Recruiting · Alexion Pharmaceuticals, Inc.

An Open-label Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Tafamidis in Patients With Transthyretin-mediated Amyloidosis Post Orthotopic Heart Transplantation

Phase 4 · Active, not recruiting · University of Texas Southwestern Medical Center

[64Cu]FBP8 PET for Early Detection of Intracardiac Thrombus in Amyloid Cardiomyopathy

Phase 3 · Recruiting · Brigham and Women's Hospital

Molecular Imaging of Myocardial Fibrosis in Cardiac Amyloidosis

Phase 3 · Active, not recruiting · Brigham and Women's Hospital

A Phase III Randomized Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin

Phase 3 · Completed · Fondazione IRCCS Policlinico San Matteo di Pavia

An Open-label, Multi-center, Non-randomized Pivotal Phase 3 Study to Evaluate the Efficacy and Safety of [18F]Florbetaben Positron Emission Tomography (PET) Imaging to Diagnose Cardiac AL Amyloidosis

Phase 3 · Completed · Lantheus Germany GmbH
Recently completed

An Open-label, Multi-center, Non-randomized Pivotal Phase 3 Study to Evaluate the Efficacy and Safety of [18F]Florbetaben Positron Emission Tomography (PET) Imaging to Diagnose Cardiac AL Amyloidosis

Phase 3 · Completed · Lantheus Germany GmbH

A Phase 3, Open-Label, Multicenter Study of I-124 Evuzamitide as an Imaging Agent for the Diagnosis of Cardiac Amyloidosis Using Positron Emission Tomography Computed Tomography (PET/CT)

Phase 3 · Completed · Sharmila Dorbala

Assessment of 18F-Florbetaben Whole-body PET Imaging for the Comprehensive Detection of Cardiac and Extracardiac Sites of Amyloid Deposits

N/A · Completed · Central Hospital, Nancy, France

Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis: A Community Study

Early Phase 1 · Completed · Mayo Clinic

A Phase III Randomized Study of Doxycycline and Tauroursodeoxycholic Acid (Doxy/TUDCA) Plus Standard Supportive Therapy Versus Standard Supportive Therapy Alone in Cardiac Amyloidosis Caused by Transthyretin

Phase 3 · Completed · Fondazione IRCCS Policlinico San Matteo di Pavia

Imaging Cardiac Amyloidosis: A Pilot Study Using F-18 Florbetapir Positron Emission Tomography

Phase 4 · Completed · Brigham and Women's Hospital

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

TTR0.57

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Transthyretinvia TTR0.57

Reference

Authoritative identity, definition & identifiers.

Synonyms

Amyloid heart disease, Amyloid heart muscle disease, Amyloidosis of heart, Senile cardiac amyloidosis, amyloid cardiomyopathy

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.