Cardiomegaly
Recent clinical, regulatory, research and industry developments relating to this disease.
NAT10 Is Involved in Cardiac Remodeling Through ac4C-Mediated Transcriptomic Regulation.
The Microenvironment of the Pathogenesis of Cardiac Hypertrophy.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial with recent milestones.
Clinical MilestonesViewHide
- 2026-08-01ClinicalMEK Inhibitors for the Treatment of Hypertrophic Cardiomyopathy in Patients With RASopathies (MEKinRAS) - Randomized Controlled TrialPrimary completion
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes5
- CD47 Antigen1
- Endothelial Cells1
- Extracellular Vesicles1
- Heart Failure1
- Ventricular Remodeling1
Leading journals3
- Cells1
- Circulation research1
- Journal of extracellular vesicles1
Leading researchers8
- Ahmadian MR1
- Amin E1
- Bazgir F1
- Chen L1
- Chun Y1
- Joung B1
- Kang JY1
- Kim H1
Affiliations (unnormalised)6
- Cardiovascular Research Center1
- Changzhou Medical Center of the Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University and Department of Cardiology of the First Affiliated Hospital of Nanjing Medical University1
- Department of Medicine and Robert M. Berne Cardiovascular Research Center1
- GNTPharma Science and Technology Center for Health1
- Graduate School of Medical Science1
- Institute of Biochemistry and Molecular Biology II1
Reference
Authoritative identity, definition & identifiers.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.