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Disease

Cerebral Small Vessel Diseases

Late-stage therapeutic developmentEmerging research
MeSHCerebral Small Vessel Diseases
2
Publications
16
Clinical trials
1
Related conditions
2025
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Early neurological deterioration in acute lacunar ischemic stroke: Systematic review of incidence, mechanisms, and prospects for treatment.

Research2024-09-05International journal of stroke : official journal of the International Stroke Society

Cerebral small vessel disease: Recent advances and future directions.

Research2023-01-01International journal of stroke : official journal of the International Stroke Society

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones.
Major developments
Major clinical milestoneImportant
Retinal Vasoreactivity is a Marker for Cerebral Small Vessel Disease Progression
Primary completion2026-06-01
Clinical Milestones1View
Recently completed 1
Activity timeline1

Clinical trials

7 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
16
All trials
3
Active
3
Late-stage
5
Completed

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20232025
Most influential

Cerebral small vessel disease: Recent advances and future directions.

International journal of stroke : official journal of the International Stroke Society · 2023 · 245 cites

Early neurological deterioration in acute lacunar ischemic stroke: Systematic review of incidence, mechanisms, and prospects for treatment.

International journal of stroke : official journal of the International Stroke Society · 2025 · 19 cites
Recent publications

Early neurological deterioration in acute lacunar ischemic stroke: Systematic review of incidence, mechanisms, and prospects for treatment.

International journal of stroke : official journal of the International Stroke Society · 2025 · 19 cites

Cerebral small vessel disease: Recent advances and future directions.

International journal of stroke : official journal of the International Stroke Society · 2023 · 245 cites
Major themes6
  • Stroke, Lacunar2
  • Cerebral Amyloid Angiopathy1
  • Cerebral Small Vessel Diseases1
  • Cognitive Dysfunction1
  • Ischemic Stroke1
  • Stroke1
Leading journals1
  • International journal of stroke : official journal of the International Stroke Society2
Leading researchers8
  • Markus HS2
  • Dawson J1
  • de Leeuw FE1
  • Doubal F1
  • Freemantle N1
  • Hassan A1
  • Le STN1
  • Mallon D1
Affiliations (unnormalised)6
  • Department of Clinical Neurosciences2
  • Center for Medical Neuroscience1
  • Centre for Clinical Brain Sciences1
  • Comprehensive Clinical Trials Unit1
  • Imperial College London1
  • Leeds General Infirmary1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Stroke, Lacunar2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE.

Identifiers
MeSHCerebral Small Vessel Diseases
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.