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Disease
Chagas Disease
Late-stage therapeutic developmentEmerging researchRising momentum
4
Publications
11
Clinical trials
2025
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Potential geographic displacement of Chagas disease vectors under climate change.
Research2025-05-21Medical and veterinary entomology
A review of neurological health disparities in Peru.
Research2023-09-07Frontiers in public health
Anti-trypanosomatid drug discovery: progress and challenges.
Research2022-08-22Nature reviews. Microbiology
WHF IASC Roadmap on Chagas Disease.
Research2020-03-30Global heart
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 2 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
- Q1 2027A Randomized, Participant- and Investigator-blinded, Controlled, Parallel Group Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LXE408 in Participants With Chronic Chagas Disease Without Severe Organ Dysfunction.
- Q3 2027Prospective, Single-arm, Multicentre Study, Using a Historical Control, to Evaluate the Efficacy/Safety and Population Pharmacokinetics of Benznidazole in Children With Chronic Indeterminate Chagas Disease
Major developments
Major trial resultsHigh impact
Results posted2026-05-11
Major trial resultsHigh impact
Results posted2026-04-09
Clinical MilestonesViewHide
Results posted
- 2026-05-11A Multicenter, Prospective, Randomized, Open-label, Blinded-endpoint, Phase 4 Study to Evaluate the Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With Chronic Chagas' Cardiomyopathy. The Study is Also Know as Prevention And Reduction of Adverse Outcomes in Chagasic Heart failUre Trial Evaluation (PARACHUTE-HF).Results posted
- 2026-04-09Short-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age: A Non-inferiority Randomized Controlled TrialResults posted
Results expected
- 2026-06-01A Randomized, Participant- and Investigator-blinded, Controlled, Parallel Group Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LXE408 in Participants With Chronic Chagas Disease Without Severe Organ Dysfunction.Results expected Q1 2027
- 2026-04-21Prospective, Single-arm, Multicentre Study, Using a Historical Control, to Evaluate the Efficacy/Safety and Population Pharmacokinetics of Benznidazole in Children With Chronic Indeterminate Chagas DiseaseResults expected Q3 2027
Recently completed
Activity timeline6
- 2026-10-30ClinicalDouble Blind, Phase III Randomized,Safety and Efficacy Non-inferiority Trial to Evaluate Two Short Benznidazole Regimens for the Treatment of Adults in the Chronic Phase of Chagas Disease in Its Indeterminate and Mild Cardiac Forms in Bolivia and ColombiaWithdrawn
- 2026-06-01ClinicalA Randomized, Participant- and Investigator-blinded, Controlled, Parallel Group Study to Assess the Efficacy, Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of LXE408 in Participants With Chronic Chagas Disease Without Severe Organ Dysfunction.Results expected Q1 2027
- 2026-06-01ClinicalPhase III Randomized,Multicenter Non-inferiority Study to Evaluate the Efficacy and Safety of Shorter Benznidazole Regimens Compared to the Standard Regimen to Treat Adult Patients With Chronic Chagas DiseasePrimary completion
- 2026-05-11ClinicalA Multicenter, Prospective, Randomized, Open-label, Blinded-endpoint, Phase 4 Study to Evaluate the Efficacy and Safety of Sacubitril/Valsartan Compared With Enalapril on Morbidity, Mortality, and NT-proBNP Change in Patients With Chronic Chagas' Cardiomyopathy. The Study is Also Know as Prevention And Reduction of Adverse Outcomes in Chagasic Heart failUre Trial Evaluation (PARACHUTE-HF).Results posted
- 2026-04-21ClinicalProspective, Single-arm, Multicentre Study, Using a Historical Control, to Evaluate the Efficacy/Safety and Population Pharmacokinetics of Benznidazole in Children With Chronic Indeterminate Chagas DiseaseResults expected Q3 2027
- 2026-04-09ClinicalShort-course Benznidazole Treatment to Reduce Trypanosoma Cruzi Parasitic Load in Women of Reproductive Age: A Non-inferiority Randomized Controlled TrialResults posted
Clinical trials
The current development programme across all trial phases.
Clinical programme
11
3
9
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Publications over time
20202025
Most influential
Major themes8
- Chagas Disease3
- Animal Distribution1
- Climate Change1
- COVID-191
- Insect Vectors1
- Leishmaniasis1
- Triatominae1
- Trypanosomiasis, African1
Leading journals4
- Frontiers in public health1
- Global heart1
- Medical and veterinary entomology1
- Nature reviews. Microbiology1
Leading researchers8
- Almubaslat F1
- Brasil LS1
- de Melo LV1
- De Rycker M1
- Diaz MM1
- Echeverría LE1
- Falconi ML1
- Forsyth C1
Affiliations (unnormalised)6
- Cardiovascular Foundation of Colombia1
- Central University of Venezuela1
- Centre for Global Chronic Conditions1
- Cumming School of Medicine Division of Cardiology1
- DAMIC Institute/Rusculleda Foundation1
- Foothills Medical Centre1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.