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Disease

Cholecystitis

Late-stage therapeutic developmentEmerging research
MeSHCholecystitis
2
Publications
16
Clinical trials
2022
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Clinical Milestones4View
Results expected 2
Recently completed 1
Other updates 1
Activity timeline4

Clinical trials

16 sponsors · 2 new · 1 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
16
All trials
5
Active
11
Late-stage
6
Completed
Late-stage studies

Upfront Endoscopic Ultrasound-guided Gallbladder Drainage (EUS-GBD) Versus Standard Protocol (Antibiotics First) for Mild to Moderate Acute Cholecystitis in Patients Who Are Very-high-risk for Cholecystectomy: A Randomized-controlled Trial.

Phase 3 · Recruiting · Chinese University of Hong Kong

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Patients With Chronic Cholecystitis and Biliary Tract Dyskinesia

Phase 3 · Recruiting · Valenta Pharm JSC

Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy

Phase 2/3 · Recruiting · Sahiwal medical college sahiwal

Clinical Study on the Effect of Tegileridine on Postoperative Pain in PatientsUndergoing Abdominal Surgery：A Randomized Controlled Double-blind Trial.

Phase 4 · Completed · Xin Chen

Intravenous Injection Versus Transhepatic Intracholecystic Injection of Indocyanine Green (ICG) to Outline Biliary Tree During Laparoscopic Cholecystectomy

Phase 4 · Completed · Theodor Bilharz Research Institute

The Effect of Hyoscine-N-Butylbromide on Nausea and Pain in Laparoscopic Cholecystectomy: A Prospective Randomized Study

Phase 4 · Completed · Saglik Bilimleri Universitesi
Recruiting

Upfront Endoscopic Ultrasound-guided Gallbladder Drainage (EUS-GBD) Versus Standard Protocol (Antibiotics First) for Mild to Moderate Acute Cholecystitis in Patients Who Are Very-high-risk for Cholecystectomy: A Randomized-controlled Trial.

Phase 3 · Recruiting · Chinese University of Hong Kong

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 3 Study to Evaluate the Efficacy, Safety, and Tolerability of 4-MUST, 128 mg Tablets in Patients With Chronic Cholecystitis and Biliary Tract Dyskinesia

Phase 3 · Recruiting · Valenta Pharm JSC

Comparison of Dexmedetomidine & Lignocaine Infusion on Perioperative Hemodynamics, Postoperative Analgesia & Recovery of Postoperative Gastrointestinal Function in Patients for Laparoscopic Cholecystectomy

Phase 2/3 · Recruiting · Sahiwal medical college sahiwal

Evaluation of Post-Operative Analgesic Efficacy of Bilateral External Oblique Intercostal Plane Block Versus Wound Site Infiltration Control Group in Patients Underwent Laparoscopic Cholecystectomy Surgery

N/A · Recruiting · Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Recently completed

Clinical Study on the Effect of Tegileridine on Postoperative Pain in PatientsUndergoing Abdominal Surgery：A Randomized Controlled Double-blind Trial.

Phase 4 · Completed · Xin Chen

Intravenous Injection Versus Transhepatic Intracholecystic Injection of Indocyanine Green (ICG) to Outline Biliary Tree During Laparoscopic Cholecystectomy

Phase 4 · Completed · Theodor Bilharz Research Institute

The Effect of Hyoscine-N-Butylbromide on Nausea and Pain in Laparoscopic Cholecystectomy: A Prospective Randomized Study

Phase 4 · Completed · Saglik Bilimleri Universitesi

Effect of Deep Versus Moderate Neuromuscular Blockade on Peak Airway Pressures During Elective Laparoscopic Surgery

Phase 4 · Completed · Stony Brook University

Extended Antibiotic Therapy in Postoperative of Laparoscopic Cholecystectomy Due to Acute Cholecystitis. Is it Necessary?

Phase 4 · Completed · Hospital Italiano de Buenos Aires

Opioid-free Total Intravenous Anesthesia With Propofol, Dexmedetomidine and Lidocaine Infusions for Laparoscopic Cholecystectomy; Comparison With Propofol, Remifentanil Infusions

Phase 4 · Completed · Bezmialem Vakif University

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
2017–2022
Major themes4
  • Antibiotic Prophylaxis1
  • Cholecystitis1
  • Cholelithiasis1
  • Diabetes Mellitus, Type 21
Leading journals2
  • Gastrointestinal endoscopy1
  • JAMA internal medicine1
Leading researchers8
  • Acosta RD1
  • Agrawal D1
  • Bruining DH1
  • Chandrasekhara V1
  • DeWitt JM1
  • Eloubeidi MA1
  • Fanelli RD1
  • Faulx AL1
Affiliations (unnormalised)1
  • Key Laboratory of Endocrinology of the National Health Commission1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Inflammation of the GALLBLADDER; generally caused by impairment of BILE flow, GALLSTONES in the BILIARY TRACT, infections, or other diseases.

Identifiers
MeSHCholecystitis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.