Chronic Limb-Threatening Ischemia
Recent clinical, regulatory, research and industry developments relating to this disease.
Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia.
Epidemiology of Peripheral Artery Disease and Polyvascular Disease.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q2 2027.
Clinical MilestonesViewHide
- 2026-04-09A Phase 2a Open-label Study to Assess the Safety, Tolerability, and Dosing Regimen of Antithrombotic Heparin Proteoglycan Mimetic APAC in Patients With Peripheral Arterial Occlusive Disease and Chronic Limb-threatening Ischemia Undergoing Endovascular RevascularizationResults expected Q2 2027
- 2026-04-09ClinicalA Phase 2a Open-label Study to Assess the Safety, Tolerability, and Dosing Regimen of Antithrombotic Heparin Proteoglycan Mimetic APAC in Patients With Peripheral Arterial Occlusive Disease and Chronic Limb-threatening Ischemia Undergoing Endovascular RevascularizationResults expected Q2 2027
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes6
- Angioplasty, Balloon, Coronary1
- Chronic Limb-Threatening Ischemia1
- Limb Salvage1
- Ocimum basilicum1
- Peripheral Arterial Disease1
- Vascular Surgical Procedures1
Leading journals3
- Circulation research1
- Lancet (London, England)1
- The New England journal of medicine1
Leading researchers8
- Aday AW1
- Assmann SF1
- Azarbal A1
- Azene E1
- Barleben A1
- Bate GR1
- Bradbury AW1
- Chetter I1
Affiliations (unnormalised)6
- Birmingham Clinical Trials Unit1
- Boston Medical Center1
- Department of Clinical Science and Education1
- Dudley Group NHS Foundation Trust1
- Guy's and St Thoma's NHS Foundation Trust1
- Hull York Medical School1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
A severe form of peripheral artery disease in which a hypoperfusion of the BLOOD through an organ or tissue is caused by occlusion of peripheral arterial vessels. It is associated with the presence of chronic ischemic rest pain, ulceration or GANGRENE.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.