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Disease

Cytomegalovirus Infections

Late-stage therapeutic developmentEmerging research
MeSHCytomegalovirus Infections
3
Publications
18
Clinical trials
2024
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones6View
Results expected 4
Recently completed 2
Activity timeline6

Clinical trials

15 sponsors · 2 new · 0 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
13
Late-stage
6
Completed
Late-stage studies

A Multicenter, Randomized, Controlled, Open-label Clinical Study to Evaluate the Efficacy and Safety of Letermovir Prophylaxis Duration Guided by Dynamic Monitoring of Specific T-cells for Preventing Cytomegalovirus Infection in Adult Recipients of Allogeneic Hematopoietic Stem Cell Transplantation in China.

Phase 4 · Recruiting · WeiShi

An Interventional Study of Letermovir for Secondary Prophylaxis After Treatment of Cytomegalovirus Infection in High Risk (D+/R-) Kidney and Kidney/Pancreas Transplant Recipients

Phase 3 · Recruiting · University of Wisconsin, Madison

Incidence of Cytomegalovirus Infection or Disease Using Valganciclovir Prophylaxis Versus Preemptive Therapy in Intermediate-Risk (R+) Living Donor Kidney Transplant Recipients Receiving Basiliximab-Based Immunosuppression: An Open-Label Clinical Trial (PREVAIL-KT)

Phase 4 · Active, not recruiting · University of Guadalajara

A Pilot Trial of the Tolerability and Clinical Effectiveness of Letermovir When Used for Secondary Prophylaxis to Prevent Recurrent Cytomegalovirus Disease in Solid Organ Transplant Recipients

Phase 4 · Recruiting · Tufts Medical Center

Tolerability of up to 200 Days of Valganciclovir Oral Solution or Tablets in Pediatric Kidney Transplant Recipients

Phase 4 · Completed · Hoffmann-La Roche

Intra-cameral Penetration and Efficacy of Ganciclovir Following Topical Administration of 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis

Phase 4 · Completed · Singapore National Eye Centre
Recruiting

A Multicenter, Randomized, Controlled, Open-label Clinical Study to Evaluate the Efficacy and Safety of Letermovir Prophylaxis Duration Guided by Dynamic Monitoring of Specific T-cells for Preventing Cytomegalovirus Infection in Adult Recipients of Allogeneic Hematopoietic Stem Cell Transplantation in China.

Phase 4 · Recruiting · WeiShi

An Interventional Study of Letermovir for Secondary Prophylaxis After Treatment of Cytomegalovirus Infection in High Risk (D+/R-) Kidney and Kidney/Pancreas Transplant Recipients

Phase 3 · Recruiting · University of Wisconsin, Madison

Non-Inferiority Assessment of Valacyclovir Versus Valganciclovir as Prophylaxis Against CMV and EBV Viremia in Kidney Transplant Recipients: A Single-Center Prospective Randomized Pilot Study.

N/A · Recruiting · National Taiwan University Hospital

A Pilot Trial of the Tolerability and Clinical Effectiveness of Letermovir When Used for Secondary Prophylaxis to Prevent Recurrent Cytomegalovirus Disease in Solid Organ Transplant Recipients

Phase 4 · Recruiting · Tufts Medical Center

A Pilot Study in the Treatment of Refractory Cytomegalovirus (CMV) Infections With Related Donor CMV Specific Cytotoxic T-cells (CTLs) in Children, Adolescents and Young Adult Recipients

Phase 2 · Recruiting · New York Medical College
Recently completed

Intra-cameral Penetration and Efficacy of Ganciclovir Following Topical Administration of 2% Ganciclovir Eye Drop for CMV Anterior Uveitis / Endotheliitis

Phase 4 · Completed · Singapore National Eye Centre

Cytomegalovirus Specific Cytotoxic T Lymphocyte for the Treatment of Cytomegalovirus Infection After Allogeneic Hematopoietic Stem Cell Transplantation

Phase 4 · Completed · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

A Randomized Trial Comparing Valcyte CMV Prophylaxis Versus Pre-emptive Therapy After Renal Transplantation Using Proteomics for Monitoring of Graft Alteration

Phase 3 · Completed · Hoffmann-La Roche

A Multicenter Prospective Cohort Study to Investigate if Ganciclovir Significantly Affects Spermatogenesis in Adult Male Renal Transplant Recipients Receiving up to 200 Days Valganciclovir Vs. Concurrent Untreated Matched Controls

Phase 4 · Completed · Hoffmann-La Roche

Tolerability of up to 200 Days of Valganciclovir Oral Solution or Tablets in Pediatric Kidney Transplant Recipients

Phase 4 · Completed · Hoffmann-La Roche

The Influence of Chronic Cytomegalovirus Infection on Influenza Vaccine Responses

Phase 4 · Completed · Stanford University

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Immune surveillance of cytomegalovirus in tissues.

Cellular & molecular immunology · 2024 · 23 cites

The battle between host antiviral innate immunity and immune evasion by cytomegalovirus.

Cellular and molecular life sciences : CMLS · 2024 · 18 cites

Human cytomegalovirus (CMV) dysregulates neurodevelopmental pathways in cerebral organoids.

Communications biology · 2024 · 15 cites
Recent publications

Immune surveillance of cytomegalovirus in tissues.

Cellular & molecular immunology · 2024 · 23 cites

The battle between host antiviral innate immunity and immune evasion by cytomegalovirus.

Cellular and molecular life sciences : CMLS · 2024 · 18 cites

Human cytomegalovirus (CMV) dysregulates neurodevelopmental pathways in cerebral organoids.

Communications biology · 2024 · 15 cites
Major themes7
  • Cytomegalovirus Infections3
  • Cytomegalovirus2
  • Autism Spectrum Disorder1
  • Fetal Diseases1
  • Immune Evasion1
  • Immunity, Innate1
  • Immunologic Surveillance1
Leading journals3
  • Cellular & molecular immunology1
  • Cellular and molecular life sciences : CMLS1
  • Communications biology1
Leading researchers8
  • Brizić I1
  • Egilmezer E1
  • Foster CSP1
  • Hamilton ST1
  • Jonjić S1
  • Juranić Lisnić V1
  • Li S1
  • Lisnić B1
Affiliations (unnormalised)6
  • Affiliated Hospital of Zunyi Medical University1
  • Center for Proteomics1
  • Croatian Academy of Sciences and Arts1
  • Institute for Clinical and Molecular Virology1
  • Prince of Wales Hospital1
  • School of Biotechnology and Biomolecular Sciences1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.

Identifiers
MeSHCytomegalovirus Infections
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.