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Disease

Dental Plaque

Late-stage therapeutic developmentEmerging research
MeSHDental Plaque
2
Publications
10
Clinical trials
2025
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones5View
Results expected 1
Recently completed 4
Activity timeline5

Clinical trials

7 sponsors · 2 new · 1 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
10
All trials
4
Active
6
Late-stage
6
Completed
Late-stage studies

Clinical Study to Evaluate the Comparative Efficacy of Floss, Essential Oil Mouthwashes, and an Alcohol-free CPC+Zn Mouthwash in Reducing Dental Plaque and Gingivitis

Phase 4 · Completed · Colgate Palmolive

Clinical Research Study to Evaluate the Effect of a Toothpaste Containing Chlorhexidine 0.3% in Subjects With Established Dental Plaque and Gingivitis

Phase 3 · Completed · Colgate Palmolive

Double-blind Interventional Study in Southern Vietnam: the Comparative Effects of Using 0.12% Chlorhexidine and Silver Nanoparticles Mouthwashes in Medical Students

Phase 3 · Completed · Can Tho University of Medicine and Pharmacy

Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Dental Plaque and Aid of Gum Problems

Phase 3 · Completed · Colgate Palmolive

Antiplaque and Antigingivitis Efficacy of the Combined Effect of Oral Irrigator and Chemicals (0.075% CPC): a Randomized Clinical Trial with Experimental Gingivitis Model

Phase 3 · Completed · Colgate Palmolive

Efficacy of Miswak When Compared to Fluoridated Toothpaste for the Maintenance of Oral Hygiene in Young Adults

Phase 4 · Completed · Riyadh Elm University
Recruiting

The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes: A Double Blinded Randomized Controlled Clinical Trial.

N/A · Recruiting · King Abdullah University Hospital

A 24-Week, Randomised, Controlled, Examiner-blind, Clinical Study to Evaluate the Efficacy of an Experimental Stannous Fluoride Dentifrice in Improving Gingival Health and Reducing Plaque Accumulation

N/A · Recruiting · HALEON

Effect of the Consumption of Beverages Added With Stevia Rebaudiana on Oral pH and Dental Biofilm in Adolescents

Phase 1/2 · Recruiting · Hospital Infantil de Mexico Federico Gomez

Comparison Of Clinical Effects Of Listerine And Chlorhexidine Mouth Wash In Patients Undergoing Fixed Orthodontic Treatment

N/A · Recruiting · Khyber Medical University Peshawar
Recently completed

Clinical Study to Evaluate the Comparative Efficacy of Floss, Essential Oil Mouthwashes, and an Alcohol-free CPC+Zn Mouthwash in Reducing Dental Plaque and Gingivitis

Phase 4 · Completed · Colgate Palmolive

Clinical Research Study to Evaluate the Effect of a Toothpaste Containing Chlorhexidine 0.3% in Subjects With Established Dental Plaque and Gingivitis

Phase 3 · Completed · Colgate Palmolive

Study to Assess the Efficacy of Two Brushing Regimens in the Reduction of Dental Plaque and Aid of Gum Problems

Phase 3 · Completed · Colgate Palmolive

Antiplaque and Antigingivitis Efficacy of the Combined Effect of Oral Irrigator and Chemicals (0.075% CPC): a Randomized Clinical Trial with Experimental Gingivitis Model

Phase 3 · Completed · Colgate Palmolive

Double-blind Interventional Study in Southern Vietnam: the Comparative Effects of Using 0.12% Chlorhexidine and Silver Nanoparticles Mouthwashes in Medical Students

Phase 3 · Completed · Can Tho University of Medicine and Pharmacy

Efficacy of Miswak When Compared to Fluoridated Toothpaste for the Maintenance of Oral Hygiene in Young Adults

Phase 4 · Completed · Riyadh Elm University

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20132025
Most influential

The role of bacterial biofilms in chronic infections.

APMIS. Supplementum · 2013 · 648 cites

Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition.

Frontiers in cellular and infection microbiology · 2025 · 12 cites
Recent publications

Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition.

Frontiers in cellular and infection microbiology · 2025 · 12 cites

The role of bacterial biofilms in chronic infections.

APMIS. Supplementum · 2013 · 648 cites
Major themes5
  • Bacteria1
  • Biofilms1
  • Inflammation1
  • Periodontitis1
  • Water Microbiology1
Leading journals2
  • APMIS. Supplementum1
  • Frontiers in cellular and infection microbiology1
Leading researchers7
  • Bjarnsholt T1
  • Dastgir M1
  • Fattahi S1
  • Maleki Dizaj S1
  • Memar MY1
  • Shahi S1
  • Yekani M1
Affiliations (unnormalised)5
  • Dental and Periodontal Research Center1
  • Infectious and Tropical Diseases Research Center1
  • Københavns Universitet1
  • School of Medicine1
  • Tabriz University of Medical Sciences1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.

Identifiers
MeSHDental Plaque
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.