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Disease

Developmental and epileptic encephalopathy, 19

Late-stage therapeutic development
Also known as DEE19, EIEE19, Early Infantile epileptic encephalopathy 19, GABRA1 early infantile epileptic encephalopathy+4 more

DEE19, EIEE19, Early Infantile epileptic encephalopathy 19, GABRA1 early infantile epileptic encephalopathy, developmental and epileptic encephalopathy 19, early infantile epileptic encephalopathy caused by mutation in GABRA1, epileptic encephalopathy, early infantile, 19, epileptic encephalopathy, early infantile, type 19.

21
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones8View
Results posted 1
Results expected 4
Recently completed 2
Other updates 1
Activity timeline8

Clinical trials

18 sponsors · 3 new · 1 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme
21
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Phase III Trial of Neoadjuvant Durvalumab (NSC 778709) Plus Chemotherapy Versus Chemotherapy Alone for Adults With MammaPrint High 2 Risk (MP2) Hormone Receptor (HR) Positive / Human Epidermal Growth Factor Receptor (HER2) Negative Stage II-III Breast Cancer

Phase 3 · Recruiting · National Cancer Institute (NCI)

Effects of Mazdutide on Cognitive Function in Patients With Type 2 Diabetes and Early-Stage Cognitive Impairment: A Multicenter, Randomized, Parallel-group, Double-blind, Placebo-controlled Trial

Phase 3 · Recruiting · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Safety and Efficacy of Butylphthalide Soft Capsules for Cognitive Impairment Comorbid With Focal Epilepsy in Elderly Patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Phase 4 · Recruiting · First Affiliated Hospital of Wenzhou Medical University

Identification, Assessment, and Treatment of Tardive Dyskinesia With Deutetrabenazine in Adults With Intellectual/Developmental Disabilities and Co-occurring Psychiatric and/or Behavioral Disorders

Phase 4 · Recruiting · University Hospitals Cleveland Medical Center

Metformin in Alzheimer's Dementia Prevention

Phase 2/3 · Active, not recruiting · Columbia University

Phase III Multicenter Clinical Trial Evaluating the Use of [18F]-APN-1607 Injection in Positron Emission Tomography in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Phase 3 · Recruiting · JYAMS PET Research & Development Limited
Recruiting

Phase III Trial of Neoadjuvant Durvalumab (NSC 778709) Plus Chemotherapy Versus Chemotherapy Alone for Adults With MammaPrint High 2 Risk (MP2) Hormone Receptor (HR) Positive / Human Epidermal Growth Factor Receptor (HER2) Negative Stage II-III Breast Cancer

Phase 3 · Recruiting · National Cancer Institute (NCI)

Effects of Mazdutide on Cognitive Function in Patients With Type 2 Diabetes and Early-Stage Cognitive Impairment: A Multicenter, Randomized, Parallel-group, Double-blind, Placebo-controlled Trial

Phase 3 · Recruiting · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Safety and Efficacy of Butylphthalide Soft Capsules for Cognitive Impairment Comorbid With Focal Epilepsy in Elderly Patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Phase 4 · Recruiting · First Affiliated Hospital of Wenzhou Medical University

Identification, Assessment, and Treatment of Tardive Dyskinesia With Deutetrabenazine in Adults With Intellectual/Developmental Disabilities and Co-occurring Psychiatric and/or Behavioral Disorders

Phase 4 · Recruiting · University Hospitals Cleveland Medical Center

Phase III Multicenter Clinical Trial Evaluating the Use of [18F]-APN-1607 Injection in Positron Emission Tomography in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Phase 3 · Recruiting · JYAMS PET Research & Development Limited
Recently completed

A Proof-of-concept Clinical Study to Evaluate the Impact of a Combination Nutraceutical Kit on Muscle Function, Cognitive Performance, and Immune Resilience in Older Adults.

Phase 4 · Completed · GPLIFE HEALTHCARE PRIVATE LIMITED

Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia

Phase 4 · Completed · Emory University

Assessment of the Effect of Metaxalone 640 mg (M640) on Truck Driving Ability and Cognition Compared to Tizanidine 8 mg: A Prospective, Single-blind, Within-subject Pilot Study

Phase 4 · Completed · Primus Pharmaceuticals

RCT of Neurocognitive and Neuroimaging Biomarkers: Predicting Progression Towards Dementia in Patients With Treatment-resistant Late-life Depression (OPTIMUM-Neuro RCT)

Phase 4 · Completed · Centre for Addiction and Mental Health

A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome

Phase 2/3 · Completed · University of California, Davis

A Phase 3, Multicenter Study of [18F]APN-1607 Positron Emission Tomography in Subjects With Alzheimer's Disease Compared to Healthy Subjects

Phase 3 · Completed · APRINOIA Therapeutics

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

GABRA10.76

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Gamma-aminobutyric acid receptor subunit alpha-1via GABRA10.76

Reference

Authoritative identity, definition & identifiers.

Synonyms

DEE19, EIEE19, Early Infantile epileptic encephalopathy 19, GABRA1 early infantile epileptic encephalopathy, developmental and epileptic encephalopathy 19, early infantile epileptic encephalopathy caused by mutation in GABRA1, epileptic encephalopathy, early infantile, 19, epileptic encephalopathy, early infantile, type 19

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.