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Disease

Developmental and epileptic encephalopathy, 62

Late-stage therapeutic development

Also known as DEE62, EIEE62, developmental and epileptic encephalopathy 62, epileptic encephalopathy, early infantile, 62.

24
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones11View all 11
Results posted 1
Results expected 4
Recently completed 4
Other updates 2
+3 more in the activity timeline below
Activity timeline11

Clinical trials

18 sponsors · 3 new · 3 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

A Pharmaco-Imaging Trial of Mixed Amphetamine Salts for the Treatment of ADHD in Intellectually-intact Youth With Autism Spectrum Disorder

Phase 4 · Recruiting · Gagan Joshi

Effects of Mazdutide on Cognitive Function in Patients With Type 2 Diabetes and Early-Stage Cognitive Impairment: A Multicenter, Randomized, Parallel-group, Double-blind, Placebo-controlled Trial

Phase 3 · Recruiting · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Safety and Efficacy of Butylphthalide Soft Capsules for Cognitive Impairment Comorbid With Focal Epilepsy in Elderly Patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Phase 4 · Recruiting · First Affiliated Hospital of Wenzhou Medical University

A Phase 3, Randomized, Multi-Center, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Relutrigine in Participants With DEE Followed by an Open-Label Extension

Phase 3 · Active, not recruiting · Praxis Precision Medicines

Metformin in Alzheimer's Dementia Prevention

Phase 2/3 · Active, not recruiting · Columbia University

Phase III Multicenter Clinical Trial Evaluating the Use of [18F]-APN-1607 Injection in Positron Emission Tomography in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Phase 3 · Recruiting · JYAMS PET Research & Development Limited
Recruiting

A Pharmaco-Imaging Trial of Mixed Amphetamine Salts for the Treatment of ADHD in Intellectually-intact Youth With Autism Spectrum Disorder

Phase 4 · Recruiting · Gagan Joshi

Effects of Mazdutide on Cognitive Function in Patients With Type 2 Diabetes and Early-Stage Cognitive Impairment: A Multicenter, Randomized, Parallel-group, Double-blind, Placebo-controlled Trial

Phase 3 · Recruiting · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Safety and Efficacy of Butylphthalide Soft Capsules for Cognitive Impairment Comorbid With Focal Epilepsy in Elderly Patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Phase 4 · Recruiting · First Affiliated Hospital of Wenzhou Medical University

Phase III Multicenter Clinical Trial Evaluating the Use of [18F]-APN-1607 Injection in Positron Emission Tomography in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Phase 3 · Recruiting · JYAMS PET Research & Development Limited
Recently completed

A Proof-of-concept Clinical Study to Evaluate the Impact of a Combination Nutraceutical Kit on Muscle Function, Cognitive Performance, and Immune Resilience in Older Adults.

Phase 4 · Completed · GPLIFE HEALTHCARE PRIVATE LIMITED

Biomarker-Driven Pharmacological Treatment for Autism Spectrum Disorder

Phase 4 · Completed · David Cochran

Pragmatic Trial Comparing Weight Gain in Children With Autism Taking Risperidone Versus Aripiprazole

Phase 4 · Completed · Vanderbilt University Medical Center

A 52-Week, Multicenter, Open-Label, Flexible-dose Study to Evaluate the Long-term Safety and Tolerability of Cariprazine in the Treatment of Pediatric Subjects With Schizophrenia, Bipolar I Disorder, or Autism Spectrum Disorder

Phase 3 · Completed · AbbVie

Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia

Phase 4 · Completed · Emory University

An Open-Label Extension Trial to Assess the Long-Term Safety of ZX008 (Fenfluramine Hydrochloride) Oral Solution as an Adjunctive Therapy for Seizures in Patients With Rare Seizure Disorders Such as Epileptic Encephalopathies Including Dravet Syndrome and Lennox-Gastaut Syndrome

Phase 3 · Completed · Zogenix, Inc.

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

SCN3A0.76

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Sodium channel protein type 3 subunit alphavia SCN3A0.76

Reference

Authoritative identity, definition & identifiers.

Synonyms

DEE62, EIEE62, developmental and epileptic encephalopathy 62, epileptic encephalopathy, early infantile, 62

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.