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Disease

Developmental and epileptic encephalopathy 98

Late-stage therapeutic development

Also known as DEE98.

21
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones8View
Results posted 1
Results expected 4
Recently completed 2
Other updates 1
Activity timeline8

Clinical trials

18 sponsors · 3 new · 1 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme
21
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

Phase III Trial of Neoadjuvant Durvalumab (NSC 778709) Plus Chemotherapy Versus Chemotherapy Alone for Adults With MammaPrint High 2 Risk (MP2) Hormone Receptor (HR) Positive / Human Epidermal Growth Factor Receptor (HER2) Negative Stage II-III Breast Cancer

Phase 3 · Recruiting · National Cancer Institute (NCI)

Effects of Mazdutide on Cognitive Function in Patients With Type 2 Diabetes and Early-Stage Cognitive Impairment: A Multicenter, Randomized, Parallel-group, Double-blind, Placebo-controlled Trial

Phase 3 · Recruiting · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Safety and Efficacy of Butylphthalide Soft Capsules for Cognitive Impairment Comorbid With Focal Epilepsy in Elderly Patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Phase 4 · Recruiting · First Affiliated Hospital of Wenzhou Medical University

Identification, Assessment, and Treatment of Tardive Dyskinesia With Deutetrabenazine in Adults With Intellectual/Developmental Disabilities and Co-occurring Psychiatric and/or Behavioral Disorders

Phase 4 · Recruiting · University Hospitals Cleveland Medical Center

Metformin in Alzheimer's Dementia Prevention

Phase 2/3 · Active, not recruiting · Columbia University

Phase III Multicenter Clinical Trial Evaluating the Use of [18F]-APN-1607 Injection in Positron Emission Tomography in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Phase 3 · Recruiting · JYAMS PET Research & Development Limited
Recruiting

Phase III Trial of Neoadjuvant Durvalumab (NSC 778709) Plus Chemotherapy Versus Chemotherapy Alone for Adults With MammaPrint High 2 Risk (MP2) Hormone Receptor (HR) Positive / Human Epidermal Growth Factor Receptor (HER2) Negative Stage II-III Breast Cancer

Phase 3 · Recruiting · National Cancer Institute (NCI)

Effects of Mazdutide on Cognitive Function in Patients With Type 2 Diabetes and Early-Stage Cognitive Impairment: A Multicenter, Randomized, Parallel-group, Double-blind, Placebo-controlled Trial

Phase 3 · Recruiting · The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

Safety and Efficacy of Butylphthalide Soft Capsules for Cognitive Impairment Comorbid With Focal Epilepsy in Elderly Patients: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial

Phase 4 · Recruiting · First Affiliated Hospital of Wenzhou Medical University

Identification, Assessment, and Treatment of Tardive Dyskinesia With Deutetrabenazine in Adults With Intellectual/Developmental Disabilities and Co-occurring Psychiatric and/or Behavioral Disorders

Phase 4 · Recruiting · University Hospitals Cleveland Medical Center

Phase III Multicenter Clinical Trial Evaluating the Use of [18F]-APN-1607 Injection in Positron Emission Tomography in Subjects With AD-related Cognitive Impairment and Subjects With Normal Cognitive Function

Phase 3 · Recruiting · JYAMS PET Research & Development Limited
Recently completed

A Proof-of-concept Clinical Study to Evaluate the Impact of a Combination Nutraceutical Kit on Muscle Function, Cognitive Performance, and Immune Resilience in Older Adults.

Phase 4 · Completed · GPLIFE HEALTHCARE PRIVATE LIMITED

Spironolactone Safety in African Americans With Mild Cognitive Impairment and Early Dementia

Phase 4 · Completed · Emory University

Assessment of the Effect of Metaxalone 640 mg (M640) on Truck Driving Ability and Cognition Compared to Tizanidine 8 mg: A Prospective, Single-blind, Within-subject Pilot Study

Phase 4 · Completed · Primus Pharmaceuticals

RCT of Neurocognitive and Neuroimaging Biomarkers: Predicting Progression Towards Dementia in Patients With Treatment-resistant Late-life Depression (OPTIMUM-Neuro RCT)

Phase 4 · Completed · Centre for Addiction and Mental Health

A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome

Phase 2/3 · Completed · University of California, Davis

A Phase 3, Multicenter Study of [18F]APN-1607 Positron Emission Tomography in Subjects With Alzheimer's Disease Compared to Healthy Subjects

Phase 3 · Completed · APRINOIA Therapeutics

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

ATP1A20.73

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Sodium/potassium-transporting ATPase subunit alpha-2via ATP1A20.73

Reference

Authoritative identity, definition & identifiers.

Synonyms

DEE98

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.