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Disease

Digestive System Neoplasms

Late-stage therapeutic developmentEmerging researchSteady momentum
MeSHDigestive System Neoplasms
4
Publications
15
Clinical trials
2025
Latest publication
Current focus
Therapeutic developmentInflammation & immunityDisease mechanisms & pathology
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones4View
Results expected 2
Recently completed 2
Activity timeline4

Clinical trials

13 sponsors · 1 new · 1 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
15
All trials
6
Active
5
Late-stage
6
Completed
Late-stage studies

AN INTERVENTIONAL, PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS BEVACIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN TREATMENT-NAÏVE PARTICIPANTS WITH METASTATIC COLORECTAL CANCER

Phase 3 · Recruiting · Pfizer

A Multinational, Randomized, Phase III Study of FOLFIRI With/Without Bevacizumab Versus Irinotecan With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer

Phase 3 · Recruiting · Sun Yat-sen University

A Phase 3, Multicenter, Open-label, Randomized Study of Nab-Paclitaxel Plus Gemcitabine Versus Gemcitabine Alone as Adjuvant Therapy in Subjects With Surgically Resected Pancreatic Adenocarcinoma

Phase 3 · Completed · Celgene

An Open-label, Randomized Phase 3 Study of the Efficacy and Tolerability of Linifanib (ABT-869) Versus Sorafenib in Subjects With Advanced Hepatocellular Carcinoma (HCC)

Phase 3 · Terminated · Abbott

A Multinational, Randomized, Phase III Study of XELIRI With/Without Bevacizumab Versus FOLFIRI With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer

Phase 3 · Completed · Epidemiological and Clinical Research Information Network
Recruiting

A Clinical Study to Assess the Safety, Feasibility, and Efficacy of Personalized mRNA Vaccine Encoding Neoantigen Alone in Subjects With Advanced Digestive System Neoplasms

Phase 1 · Recruiting · Sir Run Run Shaw Hospital

A Clinical Study to Assess the Safety, Feasibility, and Efficacy of Personalized mRNA Vaccine Encoding Neoantigen in Combination With Standard Adjuvant Therapy in Subjects With Resected Digestive System Neoplasms

Phase 1 · Recruiting · Sir Run Run Shaw Hospital

AN INTERVENTIONAL, PHASE 3, DOUBLE-BLIND, RANDOMIZED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF-08634404 IN COMBINATION WITH CHEMOTHERAPY VERSUS BEVACIZUMAB IN COMBINATION WITH CHEMOTHERAPY IN TREATMENT-NAÏVE PARTICIPANTS WITH METASTATIC COLORECTAL CANCER

Phase 3 · Recruiting · Pfizer

A Multinational, Randomized, Phase III Study of FOLFIRI With/Without Bevacizumab Versus Irinotecan With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer

Phase 3 · Recruiting · Sun Yat-sen University

Prospective Single-arm, Exploratory, Multicenter Phase II Clinical Study of Camrelizumab Combined With Chemoradiotherapy in the Treatment of Advanced First-line Esophageal Phosphorous Carcinoma

Phase 2 · Recruiting · Fujian Cancer Hospital
Recently completed

Prospective, Single-arm, Multicenter Clinical Study of Hepatic Artery Infusion Chemotherapy With Donafenib for Adjuvant Treatment of HCC Patients With High Risk of Recurrence After Hepatectomy.

Phase 2 · Completed · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

A Phase 3, Multicenter, Open-label, Randomized Study of Nab-Paclitaxel Plus Gemcitabine Versus Gemcitabine Alone as Adjuvant Therapy in Subjects With Surgically Resected Pancreatic Adenocarcinoma

Phase 3 · Completed · Celgene

An Open, Single Arm, Multicenter, Exploratory Phase II Clinical Trial of Anlotinib Hydrochloride Capsules Combined With CAPEOX in RAS and BRAF Wild-type Patients With Metastatic Colorectal Carcinoma as 1st Therapy

Phase 2 · Completed · Zhejiang University

A Phase 1, Randomized, Open-Label, Continuation Study of Entinostat in Combination With Pembrolizumab in Patients With Advanced Solid Tumors (SNDX-275-0141, MK3475-460/KEYNOTE-460)

Phase 1 · Completed · Syndax Pharmaceuticals

A Multinational, Randomized, Phase III Study of XELIRI With/Without Bevacizumab Versus FOLFIRI With/Without Bevacizumab As Second-line Therapy in Patients With Metastatic Colorectal Cancer

Phase 3 · Completed · Epidemiological and Clinical Research Information Network

89Zr-MMOT0530A PET Imaging in Patients With Unresectable Pancreatic or Platinum-resistant Ovarian Cancer Before Treatment With DMOT4039A. A Separate Study to the Phase I Study Protocol DMO4993g

Phase 1 · Completed · University Medical Center Groningen

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20182025
Major themes8
  • Angiogenesis Inhibitors1
  • Cholangitis1
  • Cholestasis, Extrahepatic1
  • Digestive System Neoplasms1
  • Endoscopy, Gastrointestinal1
  • Immune Checkpoint Inhibitors1
  • Tumor Microenvironment1
  • World Health Organization1
Leading journals4
  • Endoscopy1
  • Frontiers in immunology1
  • Histopathology1
  • Signal transduction and targeted therapy1
Leading researchers8
  • Betge J1
  • Blero D1
  • Carneiro F1
  • Costamagna G1
  • Cree IA1
  • Devière J1
  • Dreikhausen L1
  • Dumonceau JM1
Affiliations (unnormalised)6
  • Catholic University1
  • Digestive Endoscopy Unit Catholic University1
  • DKFZ Hector Cancer Institute at University Medical Center Mannheim1
  • Erasme University Hospital1
  • European Molecular Biology Laboratory1
  • Gedyt Endoscopy Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Tumors or cancer of the DIGESTIVE SYSTEM.

Identifiers
MeSHDigestive System Neoplasms
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.