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Disease

Dislocation

Late-stage therapeutic development

14

Clinical trials

12

Associated genes

2

Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

1 clinical trial expected to report results, the earliest in Q4 2026.
12 industry developments reported.

Upcoming Milestones

Q4 2026METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation

Major developments

Upcoming trial readoutImportant

METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation

Results expected Q4 20262025-12-04

Major clinical milestoneImportant

A Concurrent Non-Randomized Controlled Trial on Integrated Traditional Chinese and Western Medicine for Patellar Dislocation Pain

Primary completion2026-06-30

Clinical Milestones2View

Results expected 1

2025-12-04METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder DislocationResults expected Q4 2026

Recently completed 1

2026-06-30A Concurrent Non-Randomized Controlled Trial on Integrated Traditional Chinese and Western Medicine for Patellar Dislocation PainPrimary completion

Industry & Market12View all 12

2026-06-16The John Charnley Award: A Randomized Controlled Trial of Dual Mobility and Single Bearings for Patients at High Risk of Dislocation Following Primary Total Hip ArthroplastyTrial news · The Journal of Arthroplasty
2026-03-24Dual Mobility versus Conventional Total Hip Arthroplasty for Femoral Neck Fractures: A Multicenter Propensity-Matched Study on Dislocation RiskResearch news · The Journal of Arthroplasty
2026-08-05Diagnostic Accuracy of Artificial Intelligence Systems in Early Prediction of Dislocation and Aseptic Loosening After Total Hip ArthroplastyIndustry · The Journal of Arthroplasty
2026-07-13The Effect of Dual Mobility Articulations on Re-Revision After Revision for DislocationIndustry · The Journal of Arthroplasty
2026-06-29What Are the Rates of Recurrent Dislocation and Re-Revision After Revision Total Hip Arthroplasty for Instability?Industry · The Journal of Arthroplasty

+7 more in the activity timeline below

Activity timeline14

2026-08-05IndustryDiagnostic Accuracy of Artificial Intelligence Systems in Early Prediction of Dislocation and Aseptic Loosening After Total Hip ArthroplastyIndustry · The Journal of Arthroplasty
2026-07-13IndustryThe Effect of Dual Mobility Articulations on Re-Revision After Revision for DislocationIndustry · The Journal of Arthroplasty
2026-06-30ClinicalA Concurrent Non-Randomized Controlled Trial on Integrated Traditional Chinese and Western Medicine for Patellar Dislocation PainPrimary completion
2026-06-29IndustryWhat Are the Rates of Recurrent Dislocation and Re-Revision After Revision Total Hip Arthroplasty for Instability?Industry · The Journal of Arthroplasty
2026-06-16IndustryThe John Charnley Award: A Randomized Controlled Trial of Dual Mobility and Single Bearings for Patients at High Risk of Dislocation Following Primary Total Hip ArthroplastyTrial news · The Journal of Arthroplasty
2026-06-12IndustryWhat Factors Increase the Risk of Dislocation After Primary Total Hip Arthroplasty Using the Direct Anterior Approach?Industry · The Journal of Arthroplasty
2026-05-20IndustryConcordance of Dislocation Direction and Surgical Approach Is an Approach-Dependent Risk for Recurrent Instability Following Total Hip ArthroplastyIndustry · The Journal of Arthroplasty
2026-04-20IndustryInstability Following Head and Liner Exchange: Eight-Fold Reduction in Dislocation With the Direct Anterior ApproachIndustry · The Journal of Arthroplasty
2026-03-31IndustryDislocation Risk in Modern Total Hip Arthroplasty: Comparing Surgical Approaches With and Without Enabling TechnologyIndustry · The Journal of Arthroplasty
2026-03-24IndustryDual Mobility versus Conventional Total Hip Arthroplasty for Femoral Neck Fractures: A Multicenter Propensity-Matched Study on Dislocation RiskResearch news · The Journal of Arthroplasty

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

14

All trials

6

Active

5

Late-stage

6

Completed

Late-stage studies

Dual-mobility vs. Single-bearing Components in THA at "High Risk" for Prosthetic Dislocation

Phase 4 · Active, not recruiting · Rush University Medical Center

METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation

Phase 4 · Recruiting · Centre Hospitalier Universitaire de Nice

Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation in Children: an Adaptive Randomized Controlled Non-inferiority Multicenter Trial

Phase 2/3 · Recruiting · Naveen Poonai

Target-controlled Infusion With Propofol in the Emergency Department : a Prospective Study on 45 Adult Patients

Phase 4 · Completed · Centre Hospitalier Universitaire de Nice

PRP Treatment for Medial Retinaculum Tear - Randomized-Double-Blind-Placebo Control Trail

Phase 2/3 · Completed · Meir Medical Center

Recruiting

METHOXYFLURANE or Virtual Reality Headset vs Standard Analgesic Management for the Reduction of Anterior Shoulder Dislocation

Phase 4 · Recruiting · Centre Hospitalier Universitaire de Nice

Arthroscopic Assisted CC Stabilization Alone VS Additional K-wire Fixation for Acute Acromioclavicular Joint Injury, A Randomized Controlled Trial

N/A · Recruiting · Queen Savang Vadhana Memorial Hospital, Thailand

Intranasal Dexmedetomidine Plus Ketamine for Procedural Sedation in Children: an Adaptive Randomized Controlled Non-inferiority Multicenter Trial

Phase 2/3 · Recruiting · Naveen Poonai

Recently completed

Blood Flow Restriction Training Versus Standard Physical Therapy After Shoulder Stabilization Surgery: A Randomized Controlled Trial.

N/A · Completed · Keller Army Community Hospital

Tranexamic Acid Prophylaxis for Heterotopic Ossification in Elbow Fracture-Dislocation Surgery: A Prospective Randomized Trial

N/A · Completed · Assaf-Harofeh Medical Center

Target-controlled Infusion With Propofol in the Emergency Department : a Prospective Study on 45 Adult Patients

Phase 4 · Completed · Centre Hospitalier Universitaire de Nice

Transmuscular Quadratus Lumborum Block Block for Congenital Hip Dislocation Surgery: Randomized Controlled Study

N/A · Completed · Ataturk University

Randomized Clinical Trial Comparing the Spaso Maneuver Versus the Self-assisted Boss-Holzach-Matter for Anterior Shoulder Dislocations

N/A · Completed · Corporacion Parc Tauli

PRP Treatment for Medial Retinaculum Tear - Randomized-Double-Blind-Placebo Control Trail

Phase 2/3 · Completed · Meir Medical Center

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

CNTNAP20.38 ARL4C0.31 AGBL10.29 PTPRG0.29 ELAVL40.29 TBC1D40.28 GPLD10.28 FOXO60.28 HCRTR20.27 ENTREP10.27 NFIC0.24 SYNPO20.24

Disease biology

2 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Orexin receptor type 2via HCRTR20.27 Non-selective voltage-gated ion channel VDAC1via VDAC10.24

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Related entities are derived from literature co-mention (studied together) — associative, not causal.