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Disease

Drug Overdose

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHDrug Overdose
4
Publications
8
Clinical trials
1
Related conditions
1
Related treatments
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial with recent milestones.
Major developments
Trial discontinuedWorth watching
A Randomized Controlled Study to Evaluate the Efficacy of Fomepizole in the Treatment of Acetaminophen Overdose
Terminated2025-11-08
Clinical Milestones1View
Other updates 1
Activity timeline1

Research-associated treatments

Drugs and agents co-studied with this disease across the research literature — associative, not necessarily established treatments. Number shows shared papers.

Clinical trials

5 sponsors · 0 new · 0 completed in the last 12 months (net -1)

The current development programme across all trial phases.

Clinical programme
8
All trials
0
Active
2
Late-stage
6
Completed
Recently completed

A Randomized, Participant-blinded Five-arm Crossover Study With Blinded Outcome Assessment Investigating Glucagon's Cardiovascular Effects With and Without Beta-blocker-induced Cardioinhibition.

Phase 4 · Completed · University Hospital Bispebjerg and Frederiksberg

An Investigation Into the Effects of Intravenous Lipid Emulsion (ILE) on the Pharmacokinetic and Pharmacodynamic Properties of Metoprolol.

Phase 4 · Completed · Mikkel Bring Christensen

Bioavailability of Nasal Naloxone and Injected Naloxone Compared. A Randomized, Open Label, 4-way Cross-over Study

Phase 1 · Completed · Norwegian University of Science and Technology

Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use

Phase 1/2 · Completed · Norwegian University of Science and Technology

Phase 1, Pharmacokinetic Evaluation of Intranasal and Intramuscular Naloxone in Healthy Volunteers

Phase 1 · Completed · National Institute on Drug Abuse (NIDA)

A Pilot Study of the Bioavailability of Nasal Naloxone

Phase 2 · Completed · Norwegian University of Science and Technology

Research activity

4 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20212024
Most influential

Polysubstance use in the U.S. opioid crisis.

Molecular psychiatry · 2021 · 192 cites

Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest.

Anesthesiology · 2023 · 44 cites

Opioid use disorder: current trends and potential treatments.

Frontiers in public health · 2023 · 24 cites

GLP-1 Receptor Agonist Exposures Are Increasingly Common and Generally Associated with Mild Symptoms: A Single Poison Center Experience.

Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024 · 5 cites
Recent publications

GLP-1 Receptor Agonist Exposures Are Increasingly Common and Generally Associated with Mild Symptoms: A Single Poison Center Experience.

Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2024 · 5 cites

Opioid Overdose: Limitations in Naloxone Reversal of Respiratory Depression and Prevention of Cardiac Arrest.

Anesthesiology · 2023 · 44 cites

Opioid use disorder: current trends and potential treatments.

Frontiers in public health · 2023 · 24 cites

Polysubstance use in the U.S. opioid crisis.

Molecular psychiatry · 2021 · 192 cites
Major themes8
  • Drug Overdose2
  • Buprenorphine1
  • Glucagon-Like Peptide-1 Receptor Agonists1
  • Heart Arrest1
  • Hypoglycemia1
  • Hypoglycemic Agents1
  • Opiate Overdose1
  • Opioid Epidemic1
Leading journals4
  • Anesthesiology1
  • Frontiers in public health1
  • Journal of medical toxicology : official journal of the American College of Medical Toxicology1
  • Molecular psychiatry1
Leading researchers8
  • Atti S1
  • Blum K1
  • Compton WM1
  • Dahan A1
  • DuPont RL1
  • Florian J1
  • Fuehrlein BS1
  • Gold MS1
Affiliations (unnormalised)6
  • Alabama Poison Information Center1
  • Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions1
  • Brigham and Women's Hospital1
  • Center for Drug Evaluation and Research1
  • Center for Sports1
  • Institute for Behavior and Health1

Related conditions

1 match

Diseases frequently studied alongside this one. Number shows shared papers.

Opioid-Related Disorders2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Accidental or deliberate use of a medication or street drug in excess of normal dosage.

Identifiers
MeSHDrug Overdose
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.