Back to discover
Disease

Dyspareunia

Late-stage therapeutic developmentEmerging research
MeSHDyspareunia
1
Publications
12
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Clinical Milestones3View
Results expected 1
Recently completed 2
Activity timeline3

Clinical trials

10 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
12
All trials
3
Active
5
Late-stage
6
Completed
Late-stage studies

A Randomized, Double-Blind, Placebo-Controlled, Parallel- Design, Multiple-Site Study to Evaluate the Therapeutic Equivalence of Estradiol Vaginal Inserts 4 mcg (Teva Pharmaceuticals, Inc.) With IMVEXXY® (Estradiol Vaginal Inserts) (TherapeuticsMD, Inc.) in the Treatment of Dyspareunia in Women With Vulvar and Vaginal Atrophy

Phase 3 · Completed · Teva Pharmaceuticals USA

Open-Label Pilot Prospective Vulvoscopy Photography Study of Visible Changes in the Vulva, Vestibule, Vagina Pre/Post 20 Weeks of Daily Administration 60 Mg Ospemifene in Post-Menopausal Women With Dyspareunia From Vulvar Vaginal Atrophy

Phase 4 · Completed · Sue Goldstein

Open-Label Vulvoscopy Photography Study of Changes in Vulva, Vestibule, Urethral Meatus and Vagina 20 Weeks Post Daily Administration of 6.5 Mg Vaginal Prasterone in Menopausal Women With Moderate to Severe Dyspareunia

Phase 4 · Completed · San Diego Sexual Medicine

Treating Where it Hurts: A Randomized Blinded Clinical Trial of Local Estrogen to the Vulvar Vestibule for Dyspareunia in Postmenopausal Women

Phase 4 · Completed · Oregon Health and Science University

A Prospective Cohort Trial of Pelvic Floor Chemodenervation in Patients Undergoing Physical Therapy for High Tone Pelvic Floor Dysfunction

Phase 4 · Completed · EvergreenHealth
Recently completed

A Randomized, Double-Blind, Placebo-Controlled, Parallel- Design, Multiple-Site Study to Evaluate the Therapeutic Equivalence of Estradiol Vaginal Inserts 4 mcg (Teva Pharmaceuticals, Inc.) With IMVEXXY® (Estradiol Vaginal Inserts) (TherapeuticsMD, Inc.) in the Treatment of Dyspareunia in Women With Vulvar and Vaginal Atrophy

Phase 3 · Completed · Teva Pharmaceuticals USA

A Prospective Cohort Trial of Pelvic Floor Chemodenervation in Patients Undergoing Physical Therapy for High Tone Pelvic Floor Dysfunction

Phase 4 · Completed · EvergreenHealth

Open-Label Vulvoscopy Photography Study of Changes in Vulva, Vestibule, Urethral Meatus and Vagina 20 Weeks Post Daily Administration of 6.5 Mg Vaginal Prasterone in Menopausal Women With Moderate to Severe Dyspareunia

Phase 4 · Completed · San Diego Sexual Medicine

Treating Where it Hurts: A Randomized Blinded Clinical Trial of Local Estrogen to the Vulvar Vestibule for Dyspareunia in Postmenopausal Women

Phase 4 · Completed · Oregon Health and Science University

Use of Estriol at Distal Third of the Vaginal Wall Relieving Coital Pain in Women After Menopause: a Randomized, Blinded and Controlled Trial

Phase 1 · Completed · University of Sao Paulo

Open-Label Pilot Prospective Vulvoscopy Photography Study of Visible Changes in the Vulva, Vestibule, Vagina Pre/Post 20 Weeks of Daily Administration 60 Mg Ospemifene in Post-Menopausal Women With Dyspareunia From Vulvar Vaginal Atrophy

Phase 4 · Completed · Sue Goldstein

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes3
  • Estrogens1
  • Female Urogenital Diseases1
  • Menopause1
Leading journals1
  • Annals of internal medicine1
Leading researchers8
  • Abdi HI1
  • Anthony M1
  • Butler M1
  • Dahm P1
  • Danan ER1
  • Diem S1
  • Ensrud K1
  • Fok C1
Affiliations (unnormalised)4
  • Center for Care Delivery & Outcomes Research1
  • School of Public Health1
  • University of Minnesota1
  • VA Center for the Study of Healthcare Innovation1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Recurrent genital pain occurring during, before, or after SEXUAL INTERCOURSE in either the male or the female.

Identifiers
MeSHDyspareunia
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.