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Disease
Dystonia
Late-stage therapeutic developmentEmerging research
1
Publications
17
Clinical trials
2023
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Synaptic Dysfunction in Dystonia: Update From Experimental Models.
Research2023-01-01Current neuropharmacology
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 6 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
- Q1 2027A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia (Stride Dystonia)
- Q1 2027A Phase II, Multicentre, Randomised, Double-blind, Parallel-Group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IPN10200 as a Treatment for Cervical Dystonia in Adult Participants
- Q2 2027Safety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical Dystonia
- Q3 2027Understanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice Tremor
- Q4 2027IncobotulinumtoxinA (Xeomin) to Treat Focal Hand Dystonia: a Double-blind Placebo-controlled Randomized Multicenter Study: The "SwissHandSpasm" Study
Major developments
Upcoming trial readoutHigh impact
Results expected Q1 20272026-07-08
Upcoming trial readoutHigh impact
Results expected Q4 20272026-03-19
Clinical MilestonesViewHide
Results expected
- 2026-07-08A Phase II, Multicentre, Randomised, Double-blind, Parallel-Group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IPN10200 as a Treatment for Cervical Dystonia in Adult ParticipantsResults expected Q1 2027
- 2026-06-24Pharmacogenomic Contribution to the Biotransformation of Trihexyphenidyl and Development of a Precision Dosing Model for Children With Dystonia and Cerebral PalsyResults expected Q4 2029
- 2026-06-15A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia (Stride Dystonia)Results expected Q1 2027
- 2026-06-04Safety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical DystoniaResults expected Q2 2027
- 2026-03-19IncobotulinumtoxinA (Xeomin) to Treat Focal Hand Dystonia: a Double-blind Placebo-controlled Randomized Multicenter Study: The "SwissHandSpasm" StudyResults expected Q4 2027
Activity timeline6
- 2026-07-08ClinicalA Phase II, Multicentre, Randomised, Double-blind, Parallel-Group, Placebo Controlled Study to Evaluate the Efficacy and Safety of IPN10200 as a Treatment for Cervical Dystonia in Adult ParticipantsResults expected Q1 2027
- 2026-06-24ClinicalPharmacogenomic Contribution to the Biotransformation of Trihexyphenidyl and Development of a Precision Dosing Model for Children With Dystonia and Cerebral PalsyResults expected Q4 2029
- 2026-06-15ClinicalA Phase 2, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy, Safety, and Tolerability of VIM0423 in Individuals With Isolated Dystonia (Stride Dystonia)Results expected Q1 2027
- 2026-06-04ClinicalSafety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical DystoniaResults expected Q2 2027
- 2026-03-19ClinicalIncobotulinumtoxinA (Xeomin) to Treat Focal Hand Dystonia: a Double-blind Placebo-controlled Randomized Multicenter Study: The "SwissHandSpasm" StudyResults expected Q4 2027
- 2025-12-02ClinicalUnderstanding Disorder-specific Neural Pathophysiology in Laryngeal Dystonia and Voice TremorResults expected Q3 2027
Clinical trials
The current development programme across all trial phases.
Clinical programme
17
6
8
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Recent publications
Major themes2
- Dystonia1
- Dystonic Disorders1
Leading journals1
- Current neuropharmacology1
Leading researchers8
- Biella G1
- Bonsi P1
- Castagno AN1
- El Atiallah I1
- Martella G1
- Pisani A1
- Ponterio G1
- Tassone A1
Affiliations (unnormalised)3
- Laboratory of Neurophysiology and Plasticity1
- University of Pavia1
- University of Rome Tor Vergata1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
An attitude or posture due to the co-contraction of agonists and antagonist muscles in one region of the body. It most often affects the large axial muscles of the trunk and limb girdles. Conditions which feature persistent or recurrent episodes of dystonia as a primary manifestation of disease are referred to as DYSTONIC DISORDERS. (Adams et al., Principles of Neurology, 6th ed, p77)
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.