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Disease

Eclampsia

Late-stage therapeutic developmentEmerging research
MeSHEclampsia
1
Publications
18
Clinical trials
2022
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
Treatment With Aspirin After Preeclampsia: TAP Trial
Results expected Q3 20262026-06-04
Upcoming trial readoutHigh impact
Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes in Nulliparous Women After Assisted Reproductive Technology. APPART
Results expected Q3 20282026-05-07
Clinical Milestones5View
Results expected 3
Recently completed 2
Activity timeline5

Clinical trials

15 sponsors · 1 new · 1 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
15
Late-stage
6
Completed
Late-stage studies

APPLE: Aspirin to Prevent Pregnancy Loss and Preeclampsia

Phase 3 · Recruiting · University of Pennsylvania

Aspirin for the Prevention of Preeclampsia and Pregnancy Outcomes in Nulliparous Women After Assisted Reproductive Technology. APPART

Phase 3 · Recruiting · University Hospital, Toulouse

Treatment With Aspirin After Preeclampsia: TAP Trial

Phase 4 · Recruiting · Malamo Countouris

Role of Vitamin D in Prevention of Preeclampsia Recurrence in Pregnant Women With Previous History of Preeclampsia: A Randomized Controlled Trial

Phase 4 · Recruiting · Nishtar Medical University

Frequency of Recurrence of Seizures With Intravenous Versus Intramuscular Magnesium Sulphate in Women With Eclampsia

Phase 4 · Completed · Nishtar Medical University

Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU

Phase 4 · Completed · Assiut University
Recently completed

Frequency of Recurrence of Seizures With Intravenous Versus Intramuscular Magnesium Sulphate in Women With Eclampsia

Phase 4 · Completed · Nishtar Medical University

Comparison Between the Use of Phentolamine Versus Glyceryl Trinitrate for Their Effect on Renal Function in Pre-eclampsia Patients in ICU

Phase 4 · Completed · Assiut University

Effectiveness of Higher Aspirin Dosing for Prevention of Preeclampsia in High Risk Obese Gravida: An Open Label, Comparative Effectiveness, Randomized Controlled Trial (ASPREO Trial)

Phase 2/3 · Completed · The University of Texas Health Science Center, Houston

A Randomized Control Trial of Furosemide or Placebo With Usual Antihypertensives in the Antepartum Management of Severe Hypertension With Wide Pulse Pressure

Phase 3 · Completed · Melanie Maykin, MD

Use of Esomeprazole in Treatment of Early Onset Preeclampsia:a Double Blind Randomized, Placebo-controlled Trial

Phase 2/3 · Completed · Assiut University

Efficacy and Safety of One Gram Versus Two Grams Intravenous Maintenance Dose of Magnesium Sulfate in Women With Severe Pre-eclampsia: a Randomized Clinical Trial.

Phase 4 · Completed · Assiut University

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes3
  • Eclampsia1
  • Gastrointestinal Microbiome1
  • Pre-Eclampsia1
Leading journals1
  • BMC medicine1
Leading researchers8
  • Chen G1
  • Fan D1
  • Gou X1
  • Guo L1
  • Guo X1
  • Li P1
  • Lin D1
  • Liu Z1
Affiliations (unnormalised)3
  • Affiliated Foshan Maternity & Child Healthcare Hospital1
  • Foshan Fetal Medicine Research Institute1
  • School of Public Health1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Onset of HYPERREFLEXIA; SEIZURES; or COMA in a previously diagnosed pre-eclamptic patient (PRE-ECLAMPSIA).

Identifiers
MeSHEclampsia
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.