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Disease

Emergence Delirium

Late-stage therapeutic developmentEmerging research
MeSHEmergence Delirium
1
Publications
14
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Continuous Post-operative Lidocaine Infusion Following Major Reconstructive Spine Surgery in the Elderly to Minimize Delirium and Opiate Use: A Randomized Control Trial

Clinical trial2026-09-17Status changed to Completed · ClinicalTrials.gov

Impact of Sevoflurane Versus Propofol on Postoperative Delirium in Elderly Diabetic Patients Undergoing Non-Cardiac Surgery: a Multicenter, Randomized Controlled Trial

Clinical trial2026-09-15Status changed to Completed · ClinicalTrials.gov

Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients Undergoing Craniotomy: a Randomized Clinical Trial

Clinical trial2026-08-28Status changed to Completed · ClinicalTrials.gov

Improvement of Restorative Sleep and Post-surgical Insomnia Following Suvorexant Administration

Clinical trial2026-07-23Results posted · ClinicalTrials.gov

Improvement of Restorative Sleep and Post-surgical Insomnia Following Suvorexant Administration

Clinical trial2026-07-23Status changed to Completed · ClinicalTrials.gov

The Caffeine, Postoperative Delirium, and Change in Outcomes After Surgery (CAPACHINOS-2) Study

Clinical trial2026-07-16Status changed to Completed · ClinicalTrials.gov

The Effect of Administration of Sugammadex on the Occurrence of Emergence Agitation in Pediatric Strabismus Surgery-prospective Randomized Controlled Trial

Clinical trial2026-07-15Status changed to Completed · ClinicalTrials.gov

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones5View
Results expected 4
Recently completed 1
Activity timeline5

Clinical trials

11 sponsors · 3 new · 1 completed in the last 12 months (net +3)

The current development programme across all trial phases.

Clinical programme
14
All trials
6
Active
11
Late-stage
6
Completed
Late-stage studies

MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children. The MELA-PAED Trial: a Randomized, Double-blind, Placebo-controlled Trial.

Phase 3 · Recruiting · Arash Afshari

Effect of Oral Versus Intravenous Magnesium on Emergence Delirium in Children Undergoing Adenotonsillectomy: A Two-Center, Randomized, Double-Blind, Placebo-Controlled Study

Phase 2/3 · Recruiting · Tanta University

Prophylactic Effect of Dexmedetomidine-midazolam Versus Ketamine-midazolam on Emergence Delirium After Sevoflurane Anesthesia in Pediatric Cardiac Catheterization: A Randomized Controlled Study.

Phase 4 · Recruiting · Kasr El Aini Hospital

The Effect of Remimazolam on Emergence Delirium in Pediatrics Undergoing Neurosurgery With Sevoflurane Anesthesia

Phase 4 · Recruiting · Peking University First Hospital

Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine to Induce Preoperative Sedation and Attenuate Emergence Agitation in Children Undergoing Cleft Palate Repair Surgeries

Phase 4 · Recruiting · Assiut University

Effect of Dexmedetomidine-esketamine Combined Nasal Administration on Emergence Delirium in Elderly Patients After Surgery: a Randomized, Double-blind, Placebo-controlled Trial

Phase 4 · Completed · Peking University First Hospital
Recruiting

MELAtonin for Prevention of Postoperative Agitation and Emergence Delirium in Children. The MELA-PAED Trial: a Randomized, Double-blind, Placebo-controlled Trial.

Phase 3 · Recruiting · Arash Afshari

Effect of Oral Versus Intravenous Magnesium on Emergence Delirium in Children Undergoing Adenotonsillectomy: A Two-Center, Randomized, Double-Blind, Placebo-Controlled Study

Phase 2/3 · Recruiting · Tanta University

Prophylactic Effect of Dexmedetomidine-midazolam Versus Ketamine-midazolam on Emergence Delirium After Sevoflurane Anesthesia in Pediatric Cardiac Catheterization: A Randomized Controlled Study.

Phase 4 · Recruiting · Kasr El Aini Hospital

The Effect of Remimazolam on Emergence Delirium in Pediatrics Undergoing Neurosurgery With Sevoflurane Anesthesia

Phase 4 · Recruiting · Peking University First Hospital

Nebulized Dexmedetomidine Combined With Ketamine Versus Nebulized Dexmedetomidine to Induce Preoperative Sedation and Attenuate Emergence Agitation in Children Undergoing Cleft Palate Repair Surgeries

Phase 4 · Recruiting · Assiut University

The Effect of Dormicum-Ketamine Versus Dexmedetomidine on Emergence Delirium During Deep Sedation in Paediatric Burn Patients

Phase 2 · Recruiting · Ain Shams University
Recently completed

The Effect of Administration of Sugammadex on the Occurrence of Emergence Agitation in Pediatric Strabismus Surgery-prospective Randomized Controlled Trial

Phase 4 · Completed · Konkuk University Medical Center

Effect of Dexmedetomidine-esketamine Combined Nasal Administration on Emergence Delirium in Elderly Patients After Surgery: a Randomized, Double-blind, Placebo-controlled Trial

Phase 4 · Completed · Peking University First Hospital

the Effect of the Low Dose Nalbuphine Versus Dexmedetomidine on the Prevention of Emergence Agitation After Sevoflurane Anaesthesia in Children Undergoing ENT Surgeries

Phase 2/3 · Completed · Ain Shams University

Different Anesthetic Approaches on Postoperative Emergence Agitation in Pediatric Patients Undergoing Adenotonsillectomy: a Prospective Randomized Study

N/A · Completed · Ayfer Kaya Gök

A Randomized Clinical Trial Comparing Ketamine and Fentanyl for Postoperative Pain Management and Emergence Delirium Following Pediatric Tonsillectomy and Adenoidectomy

Phase 4 · Completed · Medipol University

Prospective Cohort Study Evaluating Incidence and Correlation Between Pain and Emergence Delirium After Adenotonsillectomy in Preschool Children

Phase 4 · Completed · San Gerardo Hospital

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes1
  • Emergence Delirium1
Leading journals1
  • Anesthesiology1
Leading researchers8
  • Boxer AL1
  • Chan B1
  • Do Q1
  • Du P1
  • Du Z1
  • Kramer JH1
  • Lario-Lago A1
  • Leung JM1
Affiliations (unnormalised)3
  • Center for Gerontology1
  • Memory and Aging Center1
  • University of California San Francisco1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A form of DELIRIUM which occurs after GENERAL ANESTHESIA.

Identifiers
MeSHEmergence Delirium
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.