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Disease

End Stage Liver Disease

Late-stage therapeutic developmentEmerging research
MeSHEnd Stage Liver Disease
1
Publications
17
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Tocotrienol Against the Progression of End Stage Liver Disease

Clinical trial2026-09-08Status changed to Completed · ClinicalTrials.gov

Cardiovascular disease assessment and management in liver transplantation.

Research2024-11-01European heart journal

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones4View
Results expected 3
Recently completed 1
Activity timeline4

Clinical trials

13 sponsors · 1 new · 1 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
17
All trials
4
Active
6
Late-stage
6
Completed
Late-stage studies

Intraoperative Angiotensin 2 for the Prevention of Kidney Injury After Liver Transplant

Phase 4 · Active, not recruiting · University of California, Los Angeles

A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation

Phase 4 · Completed · Yonsei University

A Pilot Study to Determine the Safety and Efficacy of Induction-Therapy, De Novo MPA and Delayed mTOR-Inhibition in Liver Transplant Recipients With Impaired Renal Function. (PATRON-Study)

Phase 3 · Completed · University of Regensburg

An Open-Label, Randomized, Prospective Multicenter Study To Compare The Efficacy And Safety Among 3 Immunosuppressant Treatment Regimens In Patients Receiving A Liver Transplant For ESLD Caused By Chronic Hepatitis C

Phase 4 · Completed · Baylor Research Institute

Pan-genotypic Direct Acting Antiviral Therapy in Donor HCV-positive to Recipient HCV-negative Liver Transplant

Phase 4 · Terminated · Massachusetts General Hospital

Impact of Repurposed Growth Hormone Treatment on Clinical, Nutritional, Immunological and Regenerative Parameters in Decompensated Liver Cirrhosis: a Randomized Control Trial

Phase 2/3 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh
Recently completed

Tocotrienol Against the Progression of End Stage Liver Disease

Phase 2 · Completed · Chandan Sen

Impact of Repurposed Growth Hormone Treatment on Clinical, Nutritional, Immunological and Regenerative Parameters in Decompensated Liver Cirrhosis: a Randomized Control Trial

Phase 2/3 · Completed · Post Graduate Institute of Medical Education and Research, Chandigarh

Probiotic E.Coli Nissle 1917 Comparing to Lactulose and Rifaximin in Patients With Mild (Stage 1-2) or Minimal Hepatic Encephalopathy

N/A · Completed · Bogomolets National Medical University

A Comparison of Propofol Based Total Intravenous Anesthesia and Desflurane Based Balanced Anesthesia on Hepatic Protection During Living-donor Liver Transplantation

Phase 4 · Completed · Yonsei University

A Pilot Study to Determine the Safety and Efficacy of Induction-Therapy, De Novo MPA and Delayed mTOR-Inhibition in Liver Transplant Recipients With Impaired Renal Function. (PATRON-Study)

Phase 3 · Completed · University of Regensburg

An Open-Label, Randomized, Prospective Multicenter Study To Compare The Efficacy And Safety Among 3 Immunosuppressant Treatment Regimens In Patients Receiving A Liver Transplant For ESLD Caused By Chronic Hepatitis C

Phase 4 · Completed · Baylor Research Institute

Research activity

1 paper

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Cardiovascular disease assessment and management in liver transplantation.

European heart journal · 2024 · 14 cites
Recent publications

Cardiovascular disease assessment and management in liver transplantation.

European heart journal · 2024 · 14 cites
Major themes3
  • Cardiovascular Diseases1
  • End Stage Liver Disease1
  • Liver Transplantation1
Leading journals1
  • European heart journal1
Leading researchers7
  • Accardo C1
  • Crespo G1
  • Gandolfo C1
  • Gruttadauria S1
  • Harinstein ME1
  • Humar A1
  • VanWagner LB1
Affiliations (unnormalised)6
  • Heart and Vascular Institute1
  • Hospital Clínic1
  • University of Catania1
  • University of Pittsburgh Medical Center1
  • University of Texas Southwestern Medical Center1
  • UPMC IRCCS-ISMETT (Mediterranean Institute for Transplantation and Advanced Specialized Therapies)1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Final stage of a liver disease when the liver failure is irreversible and LIVER TRANSPLANTATION is needed.

Identifiers
MeSHEnd Stage Liver Disease
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.