Back to discover
Disease

Eosinophilia

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHEosinophilia
3
Publications
11
Clinical trials
2
Related conditions
2016
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Phase 2 Study of Ruxolitinib in Idiopathic Hypereosinophilic Syndrome and Primary Eosinophilic Disorders

Clinical trial2026-09-01Status changed to Active, not recruiting · ClinicalTrials.gov

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q1 2029.
  • 1 industry development reported.
Upcoming Milestones
Clinical Milestones3View
Results posted 1
Results expected 1
Recently completed 1
Industry & Market1View
Activity timeline4

Clinical trials

9 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
11
All trials
2
Active
4
Late-stage
5
Completed
Late-stage studies

Treatment of Rhinosinusitis With Nasal Polyposis With Dupilumab and Mepolizumab: A Randomized, Multi-centre, Head-to-head Comparison in Real-world Danish Patients

Phase 4 · Active, not recruiting · Rigshospitalet, Denmark

Assessment of Glucocorticoid Responsiveness and Mechanisms of Resistance in Hypereosinophilic Syndromes

Phase 4 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

A Multicenter, Double-blind, Placebo-controlled, Study to to Evaluate the Corticosteroid- Sparing Effects of Mepolizumab in Subjects With Hypereosinophilic Syndromes (HES) and Evaluate Efficacy and Safety of Mepolizumab in Controlling the Clinical Signs and Symptoms of Subjects With HES

Phase 3 · Completed · GlaxoSmithKline

A Randomised Controlled Trial of Mepolizumab Initiated Following Admission to Hospital for a Severe Exacerbation of Eosinophilic COPD

Phase 2/3 · Completed · University of Leicester
Recently completed

A Randomised Controlled Trial of Mepolizumab Initiated Following Admission to Hospital for a Severe Exacerbation of Eosinophilic COPD

Phase 2/3 · Completed · University of Leicester

Assessment of Glucocorticoid Responsiveness and Mechanisms of Resistance in Hypereosinophilic Syndromes

Phase 4 · Completed · National Institute of Allergy and Infectious Diseases (NIAID)

Benralizumab Effect on Severe Chronic Rhinosinusitis With Eosinophilic Polyposis: A Phase II Randomized Placebo Controlled Trial

Phase 2 · Completed · Johns Hopkins University

Safety and Preliminary Efficacy of Dexpramipexole in Patients With Chronic Sinusitis With Nasal Polyps and Eosinophilia (CSNP-E)

Phase 2 · Completed · Knopp Biosciences

A Multicenter, Double-blind, Placebo-controlled, Study to to Evaluate the Corticosteroid- Sparing Effects of Mepolizumab in Subjects With Hypereosinophilic Syndromes (HES) and Evaluate Efficacy and Safety of Mepolizumab in Controlling the Clinical Signs and Symptoms of Subjects With HES

Phase 3 · Completed · GlaxoSmithKline

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
1985–2016
Leading journals2
  • Blood2
  • Annals of internal medicine1
Leading researchers8
  • Arber DA2
  • Bloomfield CD2
  • Borowitz MJ2
  • Le Beau MM2
  • Thiele J2
  • Vardiman JW2
  • Bennett JM1
  • Brunning RD1
Affiliations (unnormalised)6
  • University of Chicago2
  • Comprehensive Cancer Center1
  • Institute of Pathology1
  • John Hopkins Medical Institutions1
  • Massachusetts General Hospital1
  • Stanford University1

Related conditions

2 matches

Diseases frequently studied alongside this one. Number shows shared papers.

Myelodysplastic Syndromes2Myeloproliferative Disorders2

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Abnormal increase of EOSINOPHILS in the blood, tissues or organs.

Identifiers
MeSHEosinophilia
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.