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Disease

Fractures, Open

Late-stage therapeutic developmentEmerging research
MeSHFractures, Open
1
Publications
6
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials with recent milestones (1 completed or reporting results).
Major developments
Major trial resultsHigh impact
Acute Application Of Intrawound Antibiotic Powder In Open Extremity Fracture Wounds
Results posted2026-03-06
Major clinical milestoneHigh impact
Does Prophylactic Local Tobramycin Injection Lower Open Fracture Infection Rates?
Primary completion2026-07-01
Clinical Milestones2View
Results posted 1
Recently completed 1
Activity timeline2

Clinical trials

4 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
6
All trials
1
Active
4
Late-stage
1
Completed
Late-stage studies

Does Prophylactic Local Tobramycin Injection Lower Open Fracture Infection Rates?

Phase 3 · Active, not recruiting · Massachusetts General Hospital

Acute Application Of Intrawound Antibiotic Powder In Open Extremity Fracture Wounds

Phase 4 · Completed · University of Colorado, Denver

Locally Applied Antibiotics for Infection Prophylaxis in Treatment of Open Fractures

Phase 3 · Terminated · University of Virginia

Local Application of Vancomycin Powder in Grade I-IIIA Open Fractures

Phase 4 · Terminated · University of Tennessee
Recently completed

Acute Application Of Intrawound Antibiotic Powder In Open Extremity Fracture Wounds

Phase 4 · Completed · University of Colorado, Denver

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes4
  • Fractures, Open1
  • Methicillin-Resistant Staphylococcus aureus1
  • Osteomyelitis1
  • Staphylococcal Infections1
Leading journals1
  • Frontiers in immunology1
Leading researchers7
  • Chen Y1
  • Fu Y1
  • Lin Z1
  • Liu G1
  • Liu Z1
  • Lu M1
  • Yu B1
Affiliations (unnormalised)3
  • Guangdong Provincial Key Laboratory of Bone and Cartilage Regenerative Medicine1
  • Southern Medical University Nanfang Hospital1
  • Trauma Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Fractures in which there is an external wound communicating with the break of the bone.

Identifiers
MeSHFractures, Open
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.