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Disease

Gender Dysphoria

Late-stage therapeutic developmentEmerging research
MeSHGender Dysphoria
2
Publications
12
Clinical trials
2024
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q3 2026.
Upcoming Milestones
Clinical Milestones3View
Results posted 1
Results expected 1
Recently completed 1
Activity timeline3

Clinical trials

10 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
12
All trials
4
Active
6
Late-stage
5
Completed
Late-stage studies

Evaluation of the Effectiveness of Hormonal Treatment in Adolescents Suffering from Gender Dysphoria

Phase 3 · Recruiting · Assistance Publique - Hôpitaux de Paris

Development of Effective, Opioid Sparing Techniques for Peri-operative Pain Management of Transgender Patients Undergoing Gender Affirming Surgeries

Phase 3 · Recruiting · Cedars-Sinai Medical Center

Topical Estrogen: Brief Intervention to Improve Postoperative Experience for Transgender Men Undergoing Hysterectomy

Phase 3 · Recruiting · Women and Infants Hospital of Rhode Island

Counseling Among Gender Diverse Adolescents Who Use Depot Medroxyprogesterone

Phase 4 · Completed · University of Colorado, Denver

The Effect of Pectoral Blocks on Perioperative Pain in Simple Mastectomy and Breast Reduction in Gender Affirmation Surgery

Phase 4 · Completed · University of California, San Francisco

Comparison of Pharmacokinetics of 17-Beta-Estradiol Via Oral Administration With Sublingual Placement Versus Oral Administration With Swallowing of 17-Beta-estradiol in Male-to-Female Transgender Patients

Phase 4 · Terminated · MaineHealth
Recently completed

Comparing the Effects of Sublingual Estradiol Treatment Versus Oral Estradiol With Cyproterone Acetate (CPA) Treatment on The Coagulation System in Transgender Women: A Prospective, Controlled Cohort Study

N/A · Completed · Tel-Aviv Sourasky Medical Center

Counseling Among Gender Diverse Adolescents Who Use Depot Medroxyprogesterone

Phase 4 · Completed · University of Colorado, Denver

A Prospective, Randomized, Three-period Crossover, Interaction Study to Evaluate the Pharmacokinetics of Doravirine and Tenofovir Disoproxil Fumarate Co-administered With Cross-sex Hormonal Therapy in Adult HIV-negative Transgender Women

Phase 1 · Completed · Thomas Jefferson University

The Effect of Pectoral Blocks on Perioperative Pain in Simple Mastectomy and Breast Reduction in Gender Affirmation Surgery

Phase 4 · Completed · University of California, San Francisco

A Pilot Study of Subcutaneous vs. Intramuscular Testosterone for Gender Affirming Therapy

Phase 1/2 · Completed · University of British Columbia

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20172024
Major themes1
  • Gender Dysphoria1
Leading journals2
  • Archives of disease in childhood1
  • The Journal of clinical endocrinology and metabolism1
Leading researchers8
  • Cohen-Kettenis PT1
  • Fraser L1
  • Gooren L1
  • Hall R1
  • Hannema SE1
  • Hembree WC1
  • Hewitt CE1
  • Langton T1
Affiliations (unnormalised)6
  • Boston University School of Medicine1
  • Emory University School of Medicine and the Atlanta VA Medical Center1
  • Ghent University Hospital1
  • Leiden University Medical Center1
  • Mayo Clinic Evidence-Based Practice Center1
  • New York Presbyterian Hospital1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A marked difference between the individual’s expressed/experienced gender and the gender others would assign to the individual, and it must continue for at least six months. (from DSM-5)

Identifiers
MeSHGender Dysphoria
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.