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Disease
Gingivitis
Late-stage therapeutic developmentEmerging research
2
Publications
16
Clinical trials
1
Related conditions
5
Associated genes
2024
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
Clinical trial2026-10-16Status changed to Active, not recruiting · ClinicalTrials.gov
Clinical trial2026-08-13Status changed to Completed · ClinicalTrials.gov
Clinical trial2026-08-05Status changed to Completed · ClinicalTrials.gov
Cytokines in gingivitis and periodontitis: from pathogenesis to therapeutic targets.
Research2024-08-26Frontiers in immunology
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 3 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
- Q4 2026A Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy SALI-10 Oral Probiotics in Experimental Gingivitis
- Q4 2026Clinical Research Study to Assess the Efficacy of Two Brushing Regimens: 1) a Toothpaste Containing Stannous Fluoride and a Standard Manual Toothbrush as Compared to 2) a Regular Fluoride Toothpaste and Standard Manual Toothbrush in the Reduction of Established Dental Plaque and Gingivitis.
- Q4 2026The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes: A Double Blinded Randomized Controlled Clinical Trial.
Major developments
Upcoming trial readoutHigh impact
Results expected Q4 20262026-10-16
Major clinical milestoneHigh impact
Primary completion2026-09-30
Clinical MilestonesViewHide
Results expected
- 2026-10-16A Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy SALI-10 Oral Probiotics in Experimental GingivitisResults expected Q4 2026
- 2026-05-27Clinical Research Study to Assess the Efficacy of Two Brushing Regimens: 1) a Toothpaste Containing Stannous Fluoride and a Standard Manual Toothbrush as Compared to 2) a Regular Fluoride Toothpaste and Standard Manual Toothbrush in the Reduction of Established Dental Plaque and Gingivitis.Results expected Q4 2026
- 2026-01-23The Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes: A Double Blinded Randomized Controlled Clinical Trial.Results expected Q4 2026
Recently completed
- 2026-09-30Clinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High GingivitisPrimary completion
- 2026-02-27Investigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash - a Three-month Study in ItalyCompleted
- 2026-01-28Clinical Investigation to Assess the Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and Gingivitis: a 12-week Clinical Study.Completed
- 2025-12-30The Clinical Investigation of PerioGard (Test) Regimen Compared to Control Regimen in Reducing Plaque and Gingivitis - a Three-month Study in ThailandCompleted
- 2025-12-07A Randomized Three-Month Clinical Trial Evaluating Anti-Gingivitis Efficacy of Stannous Fluoride Dentifrices Relative to a Negative ControlPrimary completion
Activity timeline8
- 2026-10-16ClinicalA Randomized, Double-Blind, Placebo-Controlled Study to Determine the Efficacy SALI-10 Oral Probiotics in Experimental GingivitisResults expected Q4 2026
- 2026-09-30ClinicalClinical Study to Collect and Analyze Dental Plaque and Oral Health Measures in a Population With High Plaque/Low Gingivitis and High Plaque/High GingivitisPrimary completion
- 2026-05-27ClinicalClinical Research Study to Assess the Efficacy of Two Brushing Regimens: 1) a Toothpaste Containing Stannous Fluoride and a Standard Manual Toothbrush as Compared to 2) a Regular Fluoride Toothpaste and Standard Manual Toothbrush in the Reduction of Established Dental Plaque and Gingivitis.Results expected Q4 2026
- 2026-02-27ClinicalInvestigation of Clinical Efficacy of a New Mouthwash on Reducing Dental Plaque and Helping Prevent Gum Problems as Compared to a Control Mouthwash - a Three-month Study in ItalyCompleted
- 2026-01-28ClinicalClinical Investigation to Assess the Efficacy of a Battery Toothbrush in the Reduction of Established Plaque and Gingivitis: a 12-week Clinical Study.Completed
- 2026-01-23ClinicalThe Antiplaque and Antigingivitis Effect of Pure Green Tea Mouth Wash Compared to Placebo and Essential Oils Mouth Washes: A Double Blinded Randomized Controlled Clinical Trial.Results expected Q4 2026
- 2025-12-30ClinicalThe Clinical Investigation of PerioGard (Test) Regimen Compared to Control Regimen in Reducing Plaque and Gingivitis - a Three-month Study in ThailandCompleted
- 2025-12-07ClinicalA Randomized Three-Month Clinical Trial Evaluating Anti-Gingivitis Efficacy of Stannous Fluoride Dentifrices Relative to a Negative ControlPrimary completion
Clinical trials
The current development programme across all trial phases.
Clinical programme
16
6
10
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Publications over time
Most influential
Major themes4
- Gingivitis2
- Periodontitis2
- Cytokines1
- Periodontal Diseases1
Leading journals2
- Frontiers in immunology1
- Periodontology 20001
Leading researchers4
- Kesting M1
- Loos BG1
- Neurath N1
- Van Dyke TE1
Affiliations (unnormalised)3
- Academic Centre for Dentistry Amsterdam (ACTA)1
- Center for Clinical and Translational Research1
- Friedrich-Alexander University Erlangen-Nürnberg1
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Inflammation of gum tissue (GINGIVA) without loss of connective tissue.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.