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Disease

Gonorrhea

Late-stage therapeutic developmentEmerging researchRising momentum
MeSHGonorrhea
3
Publications
14
Clinical trials
12
Associated genes
3
Related proteins
2023
Latest publication
Current focus
Interstitial collagenase biologyNeutrophil collagenase biologyTherapeutic development
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 5 clinical trials expected to report results, the earliest in Q3 2026.
  • 1 industry development reported.
Upcoming Milestones
Clinical Milestones6View
Results posted 1
Results expected 5
Industry & Market1View
Activity timeline7

Clinical trials

12 sponsors · 4 new · 0 completed in the last 12 months (net +4)

The current development programme across all trial phases.

Clinical programme
14
All trials
6
Active
13
Late-stage
6
Completed
Late-stage studies

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Among Adolescent and Young Adult Females in the United States

Phase 4 · Recruiting · Westat

The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing Sexually Transmitted Diseases (Gonorrhea, Chlamydia, Syphilis) Among Men Who Have Sex With Men in Bangkok, Thailand.

Phase 4 · Recruiting · Bangrak STIs Center

A Phase 3 Randomized, Observer-Blind, Placebo-Controlled Study to Assess Efficacy of Meningococcal Group B (rMenB+OMV NZ (Bexsero)) in Preventing Gonococcal Infection Among South African Cis-Gender Women

Phase 3 · Active, not recruiting · University of Washington

Efficacy of a Meningococcal B Vaccine Against Neisseria Gonorrhoeae Infections Among Men Who Have Sex With Men: a Randomised-controlled Clinical Trial

Phase 3 · Active, not recruiting · Chinese University of Hong Kong

WHO-recommended Periodic Presumptive Treatment Versus Doxycycline Post-Exposure Prophylaxis for STI Control Among Cisgender Men Who Have Sex With Men in Kenya

Phase 4 · Recruiting · University of Washington

An Open-Label, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of a Single Dose of Oral Solithromycin Compared to Single-Dose Intramuscular Ceftriaxone Plus Single-Dose Oral Azithromycin in the Treatment of Male and Female Patients With Uncomplicated Urogenital Gonorrhea With or Without Concomitant Chlamydia

Phase 3 · Completed · Melinta Therapeutics, Inc.
Recruiting

Doxycycline Prophylaxis for Prevention of Sexually Transmitted Infections Among Adolescent and Young Adult Females in the United States

Phase 4 · Recruiting · Westat

The Efficacy of Doxycycline Post Exposure Prophylaxis for Preventing Sexually Transmitted Diseases (Gonorrhea, Chlamydia, Syphilis) Among Men Who Have Sex With Men in Bangkok, Thailand.

Phase 4 · Recruiting · Bangrak STIs Center

A First in Human Phase I Randomized and Controlled Trial to Test Safety and Immunogenicity of a Multivalent Vaccine Against Neisseria Gonorrhoeae

Phase 1 · Recruiting · LimmaTech Biologics AG

WHO-recommended Periodic Presumptive Treatment Versus Doxycycline Post-Exposure Prophylaxis for STI Control Among Cisgender Men Who Have Sex With Men in Kenya

Phase 4 · Recruiting · University of Washington
Recently completed

A Phase III, Randomized, Multicenter, Open-Label Study in Adolescent and Adult Participants Comparing the Efficacy and Safety of Gepotidacin to Ceftriaxone Plus Azithromycin in the Treatment of Uncomplicated Urogenital Gonorrhea Caused by Neisseria Gonorrhoeae

Phase 3 · Completed · GlaxoSmithKline

A Multi-center, Randomized, Open-label, Non Inferiority Trial to Evaluate the Efficacy and Safety of a Single, Oral Dose of Zoliflodacin Compared to a Combination of a Single Intramuscular Dose of Ceftriaxone and a Single Oral Dose of Azithromycin in the Treatment of Patients With Uncomplicated Gonorrhoea

Phase 3 · Completed · Global Antibiotics Research and Development Partnership

Evaluation of Doxycycline Post-exposure Prophylaxis to Reduce Sexually Transmitted Infections in PrEP Users and HIV-infected Men Who Have Sex With Men

Phase 4 · Completed · University of California, San Francisco

Cefixime 800 mg Plus Doxycycline 100 mg b.i.d. for 7 Days Compared to Ceftriaxone 1 g Plus Azithromycin 2 g for Treatment of Urogenital, Rectal and Pharyngeal Gonorrhoea: A Randomised Controlled Trial

Phase 4 · Completed · Bulovka Hospital

New Antibiotic Treatment Options for Uncomplicated Anogenital Gonorrhoea Infections - a Double-blind Randomized Controlled Non-inferiority Trial

Phase 3 · Completed · Public Health Service of Amsterdam

An Open-Label, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of a Single Dose of Oral Solithromycin Compared to Single-Dose Intramuscular Ceftriaxone Plus Single-Dose Oral Azithromycin in the Treatment of Male and Female Patients With Uncomplicated Urogenital Gonorrhea With or Without Concomitant Chlamydia

Phase 3 · Completed · Melinta Therapeutics, Inc.

Research activity

3 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20212023
Most influential

New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.

Molecules (Basel, Switzerland) · 2021 · 302 cites

Trachoma.

Nature reviews. Disease primers · 2022 · 118 cites

Immune responses to <i>Neisseria gonorrhoeae</i> and implications for vaccine development.

Frontiers in immunology · 2023 · 26 cites
Recent publications

Immune responses to <i>Neisseria gonorrhoeae</i> and implications for vaccine development.

Frontiers in immunology · 2023 · 26 cites

Trachoma.

Nature reviews. Disease primers · 2022 · 118 cites

New Antibiotics for Multidrug-Resistant Bacterial Strains: Latest Research Developments and Future Perspectives.

Molecules (Basel, Switzerland) · 2021 · 302 cites
Major themes6
  • Gonorrhea2
  • Drug Design1
  • Drug Resistance, Multiple, Bacterial1
  • Sex Workers1
  • Trachoma1
  • Trichiasis1
Leading journals3
  • Frontiers in immunology1
  • Molecules (Basel, Switzerland)1
  • Nature reviews. Disease primers1
Leading researchers8
  • Belcher T1
  • Burton MJ1
  • Dold C1
  • Gower EW1
  • Harding-Esch EM1
  • MacLennan CA1
  • Oldenburg CE1
  • Pregnolato M1
Affiliations (unnormalised)6
  • Clinical Research Department1
  • Francis I Proctor Foundation1
  • Gillings School of Global Public Health1
  • International Centre for Eye Health1
  • Jenner Institute1
  • Melbourne School of Population Health1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

MMP10.39MMP80.39CEACAM50.38CEACAM10.37CEACAM30.37CEACAM60.37LGI30.08SCG50.07CHST70.02PIH1D10.01SIGLEC160.01CHTF80.00

Disease biology

3 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Interstitial collagenasevia MMP10.39Neutrophil collagenasevia MMP80.39Cell adhesion molecule CEACAM5via CEACAM50.38

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Acute infectious disease characterized by primary invasion of the urogenital tract. The etiologic agent, NEISSERIA GONORRHOEAE, was isolated by Neisser in 1879.

Identifiers
MeSHGonorrhea
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.