Graves' Ophthalmopathy
Recent clinical, regulatory, research and industry developments relating to this disease.
The genetics of Graves' disease.
Gut microbiota and eye diseases: a bibliometric study and visualization analysis.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 2 clinical trials expected to report results, the earliest in Q4 2027.
Clinical MilestonesViewHide
- 2026-04-30The Role of Statin and Vitamin D for the Treatment of Thyroid Eye DiseaseResults expected Q4 2029
- 2026-04-29A Single-Arm, Open-Label, Exploratory Study of Tofacitinib in Patients With Glucocorticoid-Resistant or Intolerant Moderate-to-Severe Active Thyroid Eye DiseaseResults expected Q4 2027
- 2025-09-30A Randomized Controlled Trial on the Effect of Hydroxychloroquine in Mild Graves' OrbitopathyPrimary completion
- 2026-04-30ClinicalThe Role of Statin and Vitamin D for the Treatment of Thyroid Eye DiseaseResults expected Q4 2029
- 2026-04-29ClinicalA Single-Arm, Open-Label, Exploratory Study of Tofacitinib in Patients With Glucocorticoid-Resistant or Intolerant Moderate-to-Severe Active Thyroid Eye DiseaseResults expected Q4 2027
- 2026-03-09ClinicalA Phase 2, Proof-of-Concept, Randomized, Double-Masked, Placebo-Controlled Study to Determine the Efficacy and Safety of LASN01 in Patients With Thyroid Eye DiseaseResults posted
- 2025-09-30ClinicalA Randomized Controlled Trial on the Effect of Hydroxychloroquine in Mild Graves' OrbitopathyPrimary completion
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes5
- Graves Ophthalmopathy2
- Diabetic Retinopathy1
- Gastrointestinal Microbiome1
- Graves Disease1
- Macular Degeneration1
Leading journals3
- European journal of endocrinology1
- Frontiers in cellular and infection microbiology1
- Reviews in endocrine & metabolic disorders1
Leading researchers8
- Baldeschi L1
- Bartalena L1
- Chen D1
- Chen W1
- Dayan CM1
- Eckstein A1
- Fu X1
- Grixti L1
Affiliations (unnormalised)6
- Amsterdam University Medical Center1
- Cardiff University School of Medicine1
- Clinic for Ophthalmology1
- Cliniques Universitaires Saint Luc1
- Department of Clinical and Experimental Medicine1
- Johannes Gutenberg-University (JGU) Medical Center1
Reference
Authoritative identity, definition & identifiers.
An autoimmune disorder of the EYE, occurring in patients with Graves disease. Subtypes include congestive (inflammation of the orbital connective tissue), myopathic (swelling and dysfunction of the extraocular muscles), and mixed congestive-myopathic ophthalmopathy.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.