Disease

Gynecomastia

Late-stage therapeutic developmentEmerging research

MeSHGynecomastia

Publications

Clinical trials

1999

Latest publication

Latest activity

beta

Recent clinical, regulatory, research and industry developments relating to this disease.

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

Research1999-09-01The New England journal of medicine

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

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Clinical trials

3 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Late-stage studies

An OptioExtension of Trial 1033US/0006 to Assess Safety, Tolerability, Efficacy of Anastrozole (ZD1033, Arimidex™) in Treatment of Gynecomastia in Pubertal Boys Given Placebo and to Conduct a Long-Term Safety Follow-Up of Non-Responding Subjects Given Anastrozole in the Previous Trial

Phase 3 · Completed · AstraZeneca

Topical Nitroglycerin as a Mechanism for Cutaneous Vaso-modulation and Improved Wound Healing After Breast Reduction

Phase 3 · Withdrawn · Icahn School of Medicine at Mount Sinai

Recently completed

Thoracic Interfascial Plane Block Versus Thoracic Paravertebral Block for Anesthesia in Gynecomastia Surgery: A Randomized Controlled Trial

N/A · Completed · Tanta University

An Open-Label Pharmacokinetic and Pharmacodynamic Study of Anastrozole (Arimidex™) Used to Treat Pubertal Boys With Gynecomastia of Recent Onset

Phase 2 · Completed · AstraZeneca

Phase 3 · Completed · AstraZeneca

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

The New England journal of medicine · 1999 · 5,811 cites

Recent publications

The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators.

The New England journal of medicine · 1999 · 5,811 cites

Leading journals1

The New England journal of medicine1

Leading researchers8

Castaigne A1
Cody R1
Palensky J1
Perez A1
Pitt B1
Remme WJ1
Wittes J1
Zannad F1

Affiliations (unnormalised)1

University of Michigan1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.

Identifiers

MeSHGynecomastia

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.