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Disease

Heart Failure, Diastolic

Late-stage therapeutic developmentEmerging research
MeSHHeart Failure, Diastolic
2
Publications
24
Clinical trials
2021
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 6 clinical trials expected to report results, the earliest in Q4 2027.
Upcoming Milestones
Clinical Milestones16View all 16
Results expected 5
Recently completed 5
Other updates 4
+8 more in the activity timeline below
Activity timeline16

Clinical trials

17 sponsors · 7 new · 6 completed in the last 12 months (net +4)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
18
Late-stage
6
Completed
Late-stage studies

A Registry-Based Randomised Controlled Trial With Heart 4 Data - SELEnium and CoQ10 NuTrition for Heart Failure: H4D-SELEQT-HF

Phase 3 · Recruiting · Netherlands Heart Institute

A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction

Phase 3 · Recruiting · Tenax Therapeutics, Inc.

A Phase 3, Single-arm, Open-label Extension Study to Evaluate the Safety of Finerenone in Addition to Standard of Care, in Pediatric Heart Failure Patients, From Birth to 18 Years of Age, With Left Ventricular Systolic Dysfunction (LVSD)

Phase 3 · Recruiting · Bayer

Evaluation of Digoxin Therapy in Patients With Heart Failure After Acute Decompensation

Phase 4 · Recruiting · Hospital General de Agudos "Dr. Cosme Argerich"

Efficacy and Safety of NNC0487-0111 Compared to Placebo on Morbidity and Mortality in People With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Phase 3 · Recruiting · Novo Nordisk A/S

GOREISAN for Heart Failure (GOREISAN-HF) Trial

Phase 4 · Active, not recruiting · Takeshi Morimoto
Recruiting

A Registry-Based Randomised Controlled Trial With Heart 4 Data - SELEnium and CoQ10 NuTrition for Heart Failure: H4D-SELEQT-HF

Phase 3 · Recruiting · Netherlands Heart Institute

A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Levosimendan in Pulmonary Hypertension Patients With Heart Failure With Preserved Left Ventricular Ejection Fraction

Phase 3 · Recruiting · Tenax Therapeutics, Inc.

A Phase 3, Single-arm, Open-label Extension Study to Evaluate the Safety of Finerenone in Addition to Standard of Care, in Pediatric Heart Failure Patients, From Birth to 18 Years of Age, With Left Ventricular Systolic Dysfunction (LVSD)

Phase 3 · Recruiting · Bayer

Evaluation of Digoxin Therapy in Patients With Heart Failure After Acute Decompensation

Phase 4 · Recruiting · Hospital General de Agudos "Dr. Cosme Argerich"

Efficacy and Safety of NNC0487-0111 Compared to Placebo on Morbidity and Mortality in People With Heart Failure With Preserved or Mildly Reduced Ejection Fraction and Obesity

Phase 3 · Recruiting · Novo Nordisk A/S
Recently completed

A Double-blind,Randomized, Placebo-controlled Study to Assess Exercise Tolerance After Iron Repletion With Ferric Derisomaltose (Monoferric®) IV Compared to Placebo in Heart Failure With Preserved Ejection Fraction and With Iron Deficiency.

Phase 4 · Completed · Massachusetts General Hospital

A Multi-Ethnic, Multi-centre raNdomised, Controlled Trial of a Low-energy Diet for Improving Functional Status in Heart Failure With PRESERVED Ejection Fraction (AMEND-preserved)

Phase 2/3 · Completed · University of Leicester

The Effect of Dapagliflozin on Patients With Cardiomyopathy

Phase 4 · Completed · May Mohamed Abdalla

The Effect of Sacubitril and Valsartan on Heart Function in Chronic Hemodialysis Patients With HFpEF

Phase 4 · Completed · University Clinical Hospital Mostar

Empagliflozin for Patients With Acutely Decompensated Congestive Heart Failure, Diuretic Resistance, and Moderate to Advanced Chronic Kidney Disease

Phase 4 · Completed · McGill University Health Centre/Research Institute of the McGill University Health Centre

Sacubitril-Valsartan in Heart Failure With Preserved Ejection Fraction and Secondary Mitral Valve Regurgitation

Phase 4 · Completed · Ziekenhuis Oost-Limburg

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
2019–2021
Major themes2
  • Algorithms1
  • Clinical Decision-Making1
Leading journals2
  • Cardiovascular research1
  • European heart journal1
Leading researchers8
  • de Boer RA2
  • Lam CSP2
  • Voors AA2
  • Anker SD1
  • Boogerd CJ1
  • Dokter MM1
  • Donal E1
  • Edelmann F1
Affiliations (unnormalised)6
  • Amsterdam University Medical Center1
  • Berlin Institute of Health (BIH)1
  • Berlin Institute of Health (BIH) Center for Regenerative Therapies (BCRT)1
  • Boston University School of Medicine1
  • Brigham and Women's Hospital1
  • Charité - Universitätsmedizin Berlin1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.

Identifiers
MeSHHeart Failure, Diastolic
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.