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Disease

Helminthiasis

Late-stage therapeutic developmentEmerging research
MeSHHelminthiasis
1
Publications
10
Clinical trials
1
Associated genes
2008
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Helminth infections: the great neglected tropical diseases.

Research2008-04-01The Journal of clinical investigation

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials with recent milestones (1 completed or reporting results).
Clinical Milestones2View
Results posted 1
Recently completed 1
Activity timeline2

Clinical trials

9 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
10
All trials
1
Active
6
Late-stage
6
Completed
Late-stage studies

A Phase 3, Multi-center, Prospective, Randomized, Double-blind, Placebo- Controlled Study to Evaluate the Effectiveness and Safety of ZP5-9676 for the Treatment of Hookworm (Ancylostoma Duodenale and Necator Americanus), Ascaris Lumbricoides, and Trichuris Trichiura in Pediatric and Adult Participants

Phase 3 · Recruiting · Zero Point Five Therapeutics

Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) DeWorm3 Project

Phase 3 · Completed · University of Washington

A Randomized, Double-blind, Placebo-controlled Trial to Evaluate the Impact of Anthelmintic Treatment on the Incidence of Diarrheal Disease in School Children in Southern Vietnam

Phase 4 · Withdrawn · Oxford University Clinical Research Unit, Vietnam

The Impact of Different Treatment Strategies on the Transmission Dynamics of Soil-transmitted Helminths: a Cluster Randomised Trial in Kenya

Phase 4 · Completed · London School of Hygiene and Tropical Medicine

Design and Clinical Evaluation of a School Meal With Deworming Properties

Phase 2/3 · Completed · Kenya Medical Research Institute

Double-Blind, Placebo-Controlled, Randomized, Prospective, Two-Stage, Two-Arm Study to Evaluate the Efficaciousness and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population

Phase 4 · Completed · Janssen-Cilag Ltd.
Recently completed

Field Studies on the Feasibility of Interrupting the Transmission of Soil-transmitted Helminths (STH) DeWorm3 Project

Phase 3 · Completed · University of Washington

The Impact of Different Treatment Strategies on the Transmission Dynamics of Soil-transmitted Helminths: a Cluster Randomised Trial in Kenya

Phase 4 · Completed · London School of Hygiene and Tropical Medicine

Bioavailability and Safety of Two Oral Fixed Dose Preparations Containing 18 mg Ivermectin (IVM 18 MG TABLETS, LICONSA S.A., Spain) Versus Reference Dosing (Weight Based) Containing 6 mg Ivermectin (REVECTINA, Abbott Laboratórios do Brasil Ltda, Brazil)

Phase 1 · Completed · Insud Pharma

Design and Clinical Evaluation of a School Meal With Deworming Properties

Phase 2/3 · Completed · Kenya Medical Research Institute

Impact of Repeated Anthelminthic Treatment on Malaria in School Children: an Individual Randomized, Double-blind, Placebo-controlled Trial in Western Kenya

N/A · Completed · London School of Hygiene and Tropical Medicine

Double-Blind, Placebo-Controlled, Randomized, Prospective, Two-Stage, Two-Arm Study to Evaluate the Efficaciousness and Safety of a Double Treatment Plan Using a Combination of Mebendazole and Quinfamide for Treating Intestinal Helminthiasis and Amebiasis in the Mexican Population

Phase 4 · Completed · Janssen-Cilag Ltd.

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Helminth infections: the great neglected tropical diseases.

The Journal of clinical investigation · 2008 · 1,000 cites
Recent publications

Helminth infections: the great neglected tropical diseases.

The Journal of clinical investigation · 2008 · 1,000 cites
Major themes1
  • Tropical Climate1
Leading journals1
  • The Journal of clinical investigation1
Leading researchers6
  • Bethony JM1
  • Brindley PJ1
  • Hotez PJ1
  • Jacobson J1
  • King CH1
  • Pearce EJ1
Affiliations (unnormalised)1
  • George Washington University School of Medicine and Health Sciences1

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

SPATA31A70.00

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Infestation with parasitic worms of the helminth class.

Identifiers
MeSHHelminthiasis
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.