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Disease

Hematoma

Late-stage therapeutic developmentEmerging research
MeSHHematoma
2
Publications
18
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 4 clinical trials expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma
Results expected Q1 20272026-05-29
Upcoming trial readoutHigh impact
Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.
Results expected Q4 20262026-04-29
Clinical Milestones5View
Results posted 1
Results expected 4
Activity timeline5

Clinical trials

18 sponsors · 2 new · 0 completed in the last 12 months (net +2)

The current development programme across all trial phases.

Clinical programme
18
All trials
6
Active
15
Late-stage
6
Completed
Late-stage studies

TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma

Phase 3 · Recruiting · Unity Health Toronto

Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma. A Double-blind, Placebo-controlled, Multicentre, Randomized Controlled Clinical Trial

Phase 3 · Recruiting · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Randomized Trial Comparing Adjuvant Tranexamic Acid Versus Surgery Alone For Chronic Subdural Hematoma

Phase 2/3 · Recruiting · St. Olavs Hospital

Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.

Phase 2/3 · Recruiting · University of Rostock

The Effect of Using Tranexamic Acid Soaked Absorbable Gelatin Sponge in Reducing Rectus Sheath Hematoma Formation After Cesarean Section in Patients Using Warfarin Compounds

Phase 4 · Completed · Cairo University

A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery

Phase 4 · Completed · University of Michigan
Recruiting

TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma

Phase 3 · Recruiting · Unity Health Toronto

Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma. A Double-blind, Placebo-controlled, Multicentre, Randomized Controlled Clinical Trial

Phase 3 · Recruiting · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)

Randomized Trial Comparing Adjuvant Tranexamic Acid Versus Surgery Alone For Chronic Subdural Hematoma

Phase 2/3 · Recruiting · St. Olavs Hospital

Investigating the Use of Intravenous Tranexamic Acid in Gender Affirming Mastectomy

Phase 2 · Recruiting · University of California, San Francisco

Prospective Clinical Investigation on Infection as a Cause of Chronic Subdural Hematoma.

Phase 2/3 · Recruiting · University of Rostock
Recently completed

A Randomized Control Trial Assessing the Effect of Topical Tranexamic Acid on Risk of Hematoma in Breast Surgery

Phase 4 · Completed · University of Michigan

The Utility of Intra-Catheter Fibrinolytics in Draining Chronic Subdural Hematomas: A Randomized Controlled Trial Pilot Study

Phase 4 · Completed · Hamilton Health Sciences Corporation

The Effect of Using Tranexamic Acid Soaked Absorbable Gelatin Sponge in Reducing Rectus Sheath Hematoma Formation After Cesarean Section in Patients Using Warfarin Compounds

Phase 4 · Completed · Cairo University

Treatment of Chronic Subdural Hematoma by Corticosteroids

Phase 3 · Completed · Rennes University Hospital

Comparison of Total Intravenous Anesthesia vs. Inhalational Anesthesia on Brain Relaxation, Subdural Pressure and Hemodynamics in Patients With Acute Subdural Hematoma Undergoing Emergency Craniotomy- A Randomized Control Trial

Phase 4 · Completed · Jawaharlal Institute of Postgraduate Medical Education & Research

Preventive EXACYL® on Perioperative Bleeding During Orthognathism of Maxillary Surgery

Phase 3 · Completed · University Hospital, Lille

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20142023
Major themes4
  • Aorta, Abdominal1
  • Aorta, Thoracic1
  • Chemokine CX3CL11
  • Infant, Newborn, Diseases1
Leading journals2
  • European heart journal1
  • Stroke1
Leading researchers8
  • Aboyans V1
  • Allmen RS1
  • Bartolomeo RD1
  • Boileau C1
  • Bossone E1
  • Chen X1
  • Dong S1
  • Eggebrecht H1
Affiliations (unnormalised)6
  • Department of Neurosurgery and Brain and Nerve Research Laboratory (Y.Z.)1
  • First Affiliated Hospital of Soochow University1
  • Institute for Fetology (P.Z.)1
  • Loma Linda University School of Medicine1
  • School of Medicine1
  • Zhujiang Hospital1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A collection of blood outside the BLOOD VESSELS. Hematoma can be localized in an organ, space, or tissue.

Identifiers
MeSHHematoma
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.