Hyperalgesia
Recent clinical, regulatory, research and industry developments relating to this disease.
Neural Plasticity in Migraine Chronification.
Vagus nerve stimulation rescues persistent pain following orthopedic surgery in adult mice.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
- 1 clinical trial expected to report results, the earliest in Q1 2027.
Clinical MilestonesViewHide
- 2026-06-03STTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic PancreatitisResults expected Q1 2027
- 2025-12-01Effect of Ultra-low Dose Naloxone on Remifentanil-Induced HyperalgesiaTerminated
- 2026-06-03ClinicalSTTEPP: Safety, Tolerability and Dose Limiting Toxicity of Lacosamide in Patients With Painful Chronic PancreatitisResults expected Q1 2027
- 2025-12-01ClinicalEffect of Ultra-low Dose Naloxone on Remifentanil-Induced HyperalgesiaTerminated
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Hyperalgesia2
- Neuralgia2
- Astrocytes1
- Central Nervous System Sensitization1
- Ephrin-B21
- Eukaryotic Initiation Factor-4E1
- gamma-Aminobutyric Acid1
- Ganglia, Spinal1
Leading journals6
- The Journal of neuroscience : the official journal of the Society for Neuroscience2
- Advanced science (Weinheim, Baden-Wurttemberg, Germany)1
- Experimental & molecular medicine1
- Pain1
- Pain physician1
- Pharmacological research1
Leading researchers8
- Baht GS1
- Birnbaumer L1
- Blasiak J1
- Caceres AI1
- Chen H1
- Chen J1
- Chen SR1
- Cheng JK1
Affiliations (unnormalised)6
- Brain Science Institute1
- Center for Cognition and Sociality1
- Center for Neuroscience and Pain Research1
- Center for Translational Pain Medicine1
- Centers for Pain Management1
- Duke Molecular Physiology Institute1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Hyperalgesia is an increased sensitivity to pain in which minimally noxious stimuli produce an exaggerated pain or discomfort response. It can arise after damage to soft tissue containing nociceptors or after injury to a peripheral nerve.
The supplied grounding supports tissue injury involving nociceptors and peripheral nerve injury as causes of hyperalgesia. It also supports opioid exposure as a cause of opioid-induced hyperalgesia, a distinct state of nociceptive sensitization in which opioid treatment paradoxically increases pain sensitivity.
Hyperalgesia reflects nociceptive sensitization, with the nervous system responding more strongly to painful input than normal. The grounding also links it to disturbed neural plasticity and altered synaptic transmission, and in opioid-induced hyperalgesia this sensitized state can emerge during opioid exposure.
Soft tissue damage involving nociceptors and peripheral nerve injury increase the likelihood of hyperalgesia. Opioid exposure is also a risk factor for opioid-induced hyperalgesia.
The supplied grounding only supports therapy as a literature topic and does not provide specific treatment recommendations for hyperalgesia. It does support that opioid-induced hyperalgesia is discussed in relation to opioid therapy, but no standard treatment modality or drug class is specified.
AI-generated summary grounded in MeSH and 2 peer-reviewed sources. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
An increased sensation of pain or discomfort produced by minimally noxious stimuli due to damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.