Disease

Hypercalcemia

Late-stage therapeutic developmentEmerging research

MeSHHypercalcemia

Publications

Clinical trials

Associated genes

2008

Latest publication

Latest activity

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Recent clinical, regulatory, research and industry developments relating to this disease.

Chronic kidney disease mineral and bone disorder in children.

Research2007-11-28Pediatric nephrology (Berlin, Germany)

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low

Key developments

1 clinical trial expected to report results, the earliest in Q4 2027.

Upcoming Milestones

Q4 2027Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Inactivating Mutations in the CYP24A1 Gene

Major developments

Upcoming trial readoutImportant

Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Inactivating Mutations in the CYP24A1 Gene

Results expected Q4 20272026-06-22

Major clinical milestoneImportant

Improving the Sensitivity of Sestamibi SPECT-CT Parathyroid Scan with Calcitonin Pre-treatment for Primary Hyperparathyroidism

Primary completion2026-06-01

Clinical Milestones2View

Results expected 1

2026-06-22Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Inactivating Mutations in the CYP24A1 GeneResults expected Q4 2027

Recently completed 1

2026-06-01Improving the Sensitivity of Sestamibi SPECT-CT Parathyroid Scan with Calcitonin Pre-treatment for Primary HyperparathyroidismPrimary completion

Activity timeline2

2026-06-22ClinicalRifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Inactivating Mutations in the CYP24A1 GeneResults expected Q4 2027
2026-06-01ClinicalImproving the Sensitivity of Sestamibi SPECT-CT Parathyroid Scan with Calcitonin Pre-treatment for Primary HyperparathyroidismPrimary completion

Clinical trials

12 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme

All trials

Active

Late-stage

Completed

Late-stage studies

Improving the Sensitivity of Sestamibi SPECT-CT Parathyroid Scan with Calcitonin Pre-treatment for Primary Hyperparathyroidism

Phase 4 · Recruiting · Joseph Sferra

An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism

Phase 3 · Completed · Kyowa Kirin Co., Ltd.

A Randomized Double-blind Placebo-controlled Study to Evaluate the Efficacy and Safety of Cinacalcet for the Treatment of Hypercalcemia in Subjects With Primary Hyperparathyroidism Unable to Undergo Parathyroidectomy

Phase 3 · Completed · Amgen

A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Safety and Efficacy of Zoledronate (4 and 8 mg) Administered Intravenously as an Adjuvant to Anticancer Therapy to Patients With Any Cancer With Bone Metastases Other Than Breast Cancer, Multiple Myeloma or Prostate Cancer

Phase 3 · Completed · Novartis

Effect of Vitamin D Treatment in Primary Hyperparathyroidism

Phase 2/3 · Completed · University of Aarhus

A Randomized, Prospective, Cross-Over Study of Calcitriol vs. Paricalcitol in the Treatment of Mineral and Bone Disease in Hemodialysis Patients

Phase 4 · Terminated · Winthrop University Hospital

Recruiting

Improving the Sensitivity of Sestamibi SPECT-CT Parathyroid Scan with Calcitonin Pre-treatment for Primary Hyperparathyroidism

Phase 4 · Recruiting · Joseph Sferra

Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Inactivating Mutations in the CYP24A1 Gene

Phase 2 · Recruiting · Children's Hospital of Philadelphia

Recently completed

Effect of Vitamin D Treatment in Primary Hyperparathyroidism

Phase 2/3 · Completed · University of Aarhus

An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism

Phase 3 · Completed · Kyowa Kirin Co., Ltd.

A Single-arm, Multicenter, Proof-of-concept Study of Denosumab in the Treatment of Hypercalcemia of Malignancy in Subjects With Elevated Serum Calcium Despite Recent Treatment With IV Bisphosphonates

Phase 2 · Completed · Amgen

Phase 3 · Completed · Amgen

Zoledronic Acid (Zometa) for the Management of Tumor-induced Hypercalcemia (TIH) and Malignant Bone Pain (MBP) in the Community: A Feasibility Study

N/A · Completed · Alberta Health services

Phase 3 · Completed · Novartis

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Chronic kidney disease mineral and bone disorder in children.

Pediatric nephrology (Berlin, Germany) · 2008 · 47 cites

Recent publications

Chronic kidney disease mineral and bone disorder in children.

Pediatric nephrology (Berlin, Germany) · 2008 · 47 cites

Leading journals1

Pediatric nephrology (Berlin, Germany)1

Leading researchers3

Bakkaloglu S1
Salusky I1
Wesseling K1

Affiliations (unnormalised)1

David Geffen School of Medicine at UCLA1

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

PAFAH20.01

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Abnormally high level of calcium in the blood.

Identifiers

MeSHHypercalcemia

References & data sources

Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
Related entities are derived from literature co-mention (studied together) — associative, not causal.