Hyperhomocysteinemia
Recent clinical, regulatory, research and industry developments relating to this disease.
N-homocysteinylation of DJ-1 promotes neurodegeneration in Parkinson's disease.
Homocysteine lowering with folic acid and B vitamins in vascular disease.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes3
- Homocysteine1
- Parkinson Disease1
- Protein Deglycase DJ-11
Leading journals2
- Aging cell1
- The New England journal of medicine1
Leading researchers8
- Arnold MJ1
- Bao A1
- Chen G1
- Fodor G1
- Genest J Jr1
- Guo T1
- Held C1
- Hu D1
Affiliations (unnormalised)5
- Department of Clinical Laboratory1
- Population Health Research Institute1
- Renmin Hospital of Wuhan University1
- Second Affiliated Hospital of Nanchang University1
- TaiKang Center for Life and Medical Sciences1
Reference
Authoritative identity, definition & identifiers.
Condition in which the plasma levels of homocysteine and related metabolites are elevated (>13.9 μmol/l). Hyperhomocysteinemia can be familial or acquired. Development of the acquired hyperhomocysteinemia is mostly associated with vitamins B and/or folate deficiency (e.g., PERNICIOUS ANEMIA, vitamin malabsorption). Familial hyperhomocysteinemia often results in a more severe elevation of total homocysteine and excretion into the urine, resulting in HOMOCYSTINURIA. Hyperhomocysteinemia is a risk factor for cardiovascular and neurodegenerative diseases, osteoporotic fractures and complications during pregnancy.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.