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Disease

Hyperpigmentation

Late-stage therapeutic developmentEmerging research
MeSHHyperpigmentation
1
Publications
15
Clinical trials
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

Skin Pigmentation Types, Causes and Treatment-A Review.

Research2023-06-18Molecules (Basel, Switzerland)

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Major developments
Upcoming trial readoutImportant
Study on the Functional Impact of Cosmetics on Improving Self-Esteem and Quality of Life in Black Women
Results expected Q4 20262026-06-04
Major clinical milestoneImportant
Clinical and Histological Evaluation of Topical Vitamin C Application Using Three Modalities in Gingival Depigmentation
Primary completion2026-05-01
Clinical Milestones5View
Results expected 1
Recently completed 3
Other updates 1
Activity timeline5

Clinical trials

13 sponsors · 1 new · 1 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
15
All trials
3
Active
5
Late-stage
6
Completed
Late-stage studies

A Control Trial of the Efficacy and Safety of 0.025% Tretinoin Cream and Cream Based in the Treatment of Axillary Hyperpigmentation Associated With Acanthosis Nigricans

Phase 3 · Completed · Srinakharinwirot University

A Prospective, Single-center, Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of Tazarotene 0.045% Lotion (Arazlo) for Treating Postinflammatory Erythema and Postinflammatory Hyperpigmentation in Subjects With Acne

Phase 4 · Completed · Dr. Emmy Graber

Topical 5% Tranexamic Acid as a Treatment for Postinflammatory Hyperpigmentation Due to Acne Vulgaris

Phase 2/3 · Withdrawn · Wayne State University

A Double Blind, Randomized Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation

Phase 4 · Completed · Universidad Autonoma de San Luis Potosí

A Single Blind, Placebo Controlled Trial to Evaluate Effects of a Study Medication, a Nu Skin Lightening Product With and Without Iontophoresis vs Tretinoin Cream vs Vehicle Control for Facial Hyperpigmentation

Phase 4 · Completed · Massachusetts General Hospital
Recently completed

A Comparative Evaluation of the Effectiveness of Topical Licorice Extract Gel and Diode Laser 445 nm on Physiologic Gingival Pigmentation

N/A · Completed · Alexandria University

A Control Trial of the Efficacy and Safety of 0.025% Tretinoin Cream and Cream Based in the Treatment of Axillary Hyperpigmentation Associated With Acanthosis Nigricans

Phase 3 · Completed · Srinakharinwirot University

A Prospective, Single-center, Pilot Study to Evaluate the Efficacy, Safety, and Tolerability of Tazarotene 0.045% Lotion (Arazlo) for Treating Postinflammatory Erythema and Postinflammatory Hyperpigmentation in Subjects With Acne

Phase 4 · Completed · Dr. Emmy Graber

Evaluation of Microinjected Amnion-derived Collagen by Dermapen in the Smoothing of Skin Wrinkles

Phase 2 · Completed · Egyptian Atomic Energy Authority

A Double Blind, Randomized Clinical Trial of 4% Niacinamide Versus 0.05% Desonide for the Treatment of Axillar Hyperpigmentation

Phase 4 · Completed · Universidad Autonoma de San Luis Potosí

A Single Blind, Placebo Controlled Trial to Evaluate Effects of a Study Medication, a Nu Skin Lightening Product With and Without Iontophoresis vs Tretinoin Cream vs Vehicle Control for Facial Hyperpigmentation

Phase 4 · Completed · Massachusetts General Hospital

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Skin Pigmentation Types, Causes and Treatment-A Review.

Molecules (Basel, Switzerland) · 2023 · 104 cites
Recent publications

Skin Pigmentation Types, Causes and Treatment-A Review.

Molecules (Basel, Switzerland) · 2023 · 104 cites
Major themes2
  • Hyperpigmentation1
  • Skin Pigmentation1
Leading journals1
  • Molecules (Basel, Switzerland)1
Leading researchers5
  • Jibreen A1
  • Karaman D1
  • Karaman R1
  • Thawabteh A1
  • Thawabteh AM1
Affiliations (unnormalised)3
  • Al-Quds University1
  • Birzeit University1
  • University of Basilicata1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Excessive pigmentation of the skin, usually as a result of increased epidermal or dermal melanin pigmentation, hypermelanosis. Hyperpigmentation can be localized or generalized. The condition may arise from exposure to light, chemicals or other substances, or from a primary metabolic imbalance.

Identifiers
MeSHHyperpigmentation
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.