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Disease
Hypoinsulinemic hypoglycemia and body hemihypertrophy
Late-stage therapeutic development
Also known as HIHGHH, hypoinsulinemic hypoglycemia with hemihypertrophy.
23
Clinical trials
12
Associated genes
1
Related proteins
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Moderate
Key developments
- 3 clinical trials expected to report results, the earliest in Q2 2027.
Upcoming Milestones
- Q2 2027A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus With Impaired Hypoglycemic Awareness and Severe Hypoglycemia
- Q3 2028Biometabolic Impact of Continuation of GLP-1 Agonists Following Bariatric
- Q3 2028Do Antipsychotics Block Insulin Action in the Brain: is it a Class Effect?
Major developments
Major trial resultsHigh impact
Results posted2026-07-02
Upcoming trial readoutHigh impact
Results expected Q2 20272026-06-30
Clinical MilestonesViewHide
Results posted
- 2026-07-02Does Insulin Sensitivity Impact the Potential of Metformin to Slow AgingResults posted
- 2025-09-22Exercise Dose and Metformin for Vascular Health in Adults With Metabolic SyndromeResults posted
Results expected
- 2026-06-30A Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus With Impaired Hypoglycemic Awareness and Severe HypoglycemiaResults expected Q2 2027
- 2026-04-02Do Antipsychotics Block Insulin Action in the Brain: is it a Class Effect?Results expected Q3 2028
- 2026-01-22Biometabolic Impact of Continuation of GLP-1 Agonists Following BariatricResults expected Q3 2028
Recently completed
Other updates
Activity timeline7
- 2026-07-02ClinicalDoes Insulin Sensitivity Impact the Potential of Metformin to Slow AgingResults posted
- 2026-06-30ClinicalA Phase 1/2/3 Study to Evaluate the Safety, Tolerability, and Efficacy of VX-880 in Subjects Who Have Type 1 Diabetes Mellitus With Impaired Hypoglycemic Awareness and Severe HypoglycemiaResults expected Q2 2027
- 2026-04-02ClinicalDo Antipsychotics Block Insulin Action in the Brain: is it a Class Effect?Results expected Q3 2028
- 2026-03-17ClinicalA Randomized, Allocation-concealed, Assessor-blinded, Parallel-group Trial Evaluating the Association Between Erectile Dysfunction and Left Ventricular Diastolic Dysfunction and Comparing the Effects of Tadalafil, SGLT2 Inhibitors, and Their Combination in Patients With Metabolic Syndrome.Completed
- 2026-01-22ClinicalBiometabolic Impact of Continuation of GLP-1 Agonists Following BariatricResults expected Q3 2028
- 2025-12-01ClinicalThe Role of Aldosterone on Sympathetic Nerve Activity and Insulin SensitivityWithdrawn
- 2025-09-22ClinicalExercise Dose and Metformin for Vascular Health in Adults With Metabolic SyndromeResults posted
Clinical trials
The current development programme across all trial phases.
Clinical programme
23
6
18
6
Late-stage studies
Recruiting
Recently completed
Associated genes
Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.
Disease biology
Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.
Reference
Authoritative identity, definition & identifiers.
Synonyms
HIHGHH, hypoinsulinemic hypoglycemia with hemihypertrophy
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Related entities are derived from literature co-mention (studied together) — associative, not causal.