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Disease

Hypomagnesemia, seizures, and intellectual disability 2

Late-stage therapeutic development

Also known as HOMGSMR2, HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION 2.

10
Clinical trials
1
Associated genes
1
Related proteins

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones4View
Results expected 2
Recently completed 1
Other updates 1
Activity timeline4

Clinical trials

10 sponsors · 1 new · 1 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
10
All trials
2
Active
7
Late-stage
6
Completed
Late-stage studies

Identification, Assessment, and Treatment of Tardive Dyskinesia With Deutetrabenazine in Adults With Intellectual/Developmental Disabilities and Co-occurring Psychiatric and/or Behavioral Disorders

Phase 4 · Recruiting · University Hospitals Cleveland Medical Center

Metformin for Antipsychotic-induced Weight Gain in Adults With Intellectual Disability: A Double-Blind Randomized Control Trial

Phase 4 · Recruiting · Centre for Addiction and Mental Health

A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome

Phase 2/3 · Completed · University of California, Davis

Detoxification From the Lipid Tract by Cocktail Design

Phase 4 · Completed · Pachankis, Yang I., M.D.

A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

Phase 4 · Completed · Joseph Cravero

Prospective, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study With an Open-label Extension Period to Investigate the Efficacy and Safety of NT 201 in the Treatment of Children and Adolescents (2-17 Years) With Chronic Troublesome Sialorrhea Associated With Neurological Disorders, and/or Intellectual Disability

Phase 3 · Completed · Merz Pharmaceuticals GmbH
Recently completed

Randomized, Double-blind, Controlled Study of Clomastine Fumarate in the Treatment of Williams Syndrome

Phase 2 · Completed · Qilu Hospital of Shandong University

Effects of the Combination of Magnesium Bisphosphonates Versus Bisphosphonates Alone on Bone Remodeling: Randomized Pilot Clinical Trial

Phase 2 · Completed · University Hospital, Clermont-Ferrand

A Double-Blind, Placebo-Controlled Trial of Metformin in Individuals With Fragile X Syndrome

Phase 2/3 · Completed · University of California, Davis

Detoxification From the Lipid Tract by Cocktail Design

Phase 4 · Completed · Pachankis, Yang I., M.D.

A Pilot Study of Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging

Phase 4 · Completed · Joseph Cravero

Prospective, Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study With an Open-label Extension Period to Investigate the Efficacy and Safety of NT 201 in the Treatment of Children and Adolescents (2-17 Years) With Chronic Troublesome Sialorrhea Associated With Neurological Disorders, and/or Intellectual Disability

Phase 3 · Completed · Merz Pharmaceuticals GmbH

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

ATP1A10.72

Disease biology

1 match

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Sodium/potassium-transporting ATPase subunit alpha-1via ATP1A10.72

Reference

Authoritative identity, definition & identifiers.

Synonyms

HOMGSMR2, HYPOMAGNESEMIA, SEIZURES, AND MENTAL RETARDATION 2

References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.