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Disease

Hyponatremia

Late-stage therapeutic developmentEmerging research
MeSHHyponatremia
2
Publications
16
Clinical trials
2020
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 2 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Clinical Milestones2View
Results expected 2
Activity timeline2

Clinical trials

12 sponsors · 1 new · 0 completed in the last 12 months (net +1)

The current development programme across all trial phases.

Clinical programme
16
All trials
4
Active
13
Late-stage
6
Completed
Late-stage studies

Effects of the SGLT2 Inhibitor Empagliflozin in Patients With Euvolemic and Hypervolemic Hyponatremia - a Multicentric Randomized Double-blind Placebo-controlled Trial (the EMPOWER Study)

Phase 4 · Recruiting · University Hospital, Basel, Switzerland

Systematic Use of DDAVP to Prevent Serum Sodium Overcorrection in Severe Hyponatremia: a Multicenter Open-label Randomized Controlled Trial

Phase 3 · Recruiting · Assistance Publique - Hôpitaux de Paris

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia

Phase 3 · Completed · CardioKine Inc.

Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial

Phase 4 · Completed · Hospital del Niño "Dr. Federico Gomez Santos"

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia

Phase 3 · Completed · Otsuka Pharmaceutical Development & Commercialization, Inc.

Efficacy and Safety of Rapid Intermittent Correction Compared With Slow Continuous Correction With Hypertonic Saline in Patient With Moderately Severe or Severe Symptomatic Severe Hyponatremia (SALSA Trial)

Phase 4 · Completed · Seoul National University Hospital
Recently completed

Early Sodium Intake in Preterm Newborns; Randomized Clinical Trial

Phase 4 · Completed · Hospital del Niño "Dr. Federico Gomez Santos"

Efficacy and Safety of Rapid Intermittent Correction Compared With Slow Continuous Correction With Hypertonic Saline in Patient With Moderately Severe or Severe Symptomatic Severe Hyponatremia (SALSA Trial)

Phase 4 · Completed · Seoul National University Hospital

Use of Isotonic Solutions Versus Hypotonic Solutions for Preventing Hospital Acquired Hyponatremia.

Phase 3 · Completed · Instituto Tecnologico y de Estudios Superiores de Monterey

Randomized, Double Blind, Controlled Trial of 0.9% NaCl/Dextrose 5% vs 0.45% NaCl/Dextrose 5% as Maintenance Intravenous Fluids in Hospitalized Children

Phase 3 · Completed · The Hospital for Sick Children

A Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Tolerability of Oral Lixivaptan Capsules in Subjects With Euvolemic Hyponatremia

Phase 3 · Completed · CardioKine Inc.

Multicenter, Randomized, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of the Effects of Titrated Oral Tolvaptan Tablets in Patients With Hyponatremia

Phase 3 · Completed · Otsuka Pharmaceutical Development & Commercialization, Inc.

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Leading journals2
  • JAMA oncology1
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology1
Leading researchers8
  • Al-Toubah TE1
  • Alese OB1
  • Bahary N1
  • Bates SE1
  • Bullock AJ1
  • Chondros D1
  • Chung V1
  • de la Fouchardiere C1
Affiliations (unnormalised)6
  • and Université de Paris1
  • Beth Israel Deaconess Medical Center1
  • Catalan Institute of Oncology (ICO)1
  • Centre Léon Bérard1
  • Columbia University Irving Medical Center1
  • Department of Internal Medicine III and Comprehensive Cancer Center1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)

Identifiers
MeSHHyponatremia
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.