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Disease

Hypospadias

Late-stage therapeutic developmentEmerging research
MeSHHypospadias
1
Publications
16
Clinical trials
2001
Latest publication
Latest activity
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Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

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Clinical trials

13 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
16
All trials
2
Active
5
Late-stage
6
Completed
Late-stage studies

Effect of Intravenous Dexamethasone in Combination With Pudendal Nerve Block on Postoperative Pain Control in Pediatric Hypospadias Repair

Phase 4 · Completed · Dr Sonia ben khalifa (PhD)

Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants? A Multi-center Prospective Randomized Trial.

Phase 4 · Completed · University of Colorado, Denver

Isoamyl 2-Cyanoacrylate Interposition in the Urethro-cutaneous Fistula Repair: A Randomized Controlled Trial.

Phase 2/3 · Completed · Ain Shams University

Caudal vs. Pudendal Block for Early Postoperative Pain Control in a Pediatric Population Undergoing Lower Genitourinary Surgery

Phase 4 · Withdrawn · University Hospitals Cleveland Medical Center

A Randomized Trial Evaluating Use of Long-Acting Liposomal Bupivacaine (Exparel®) in Reducing Narcotic Pain Requirements in Pediatric Patients Undergoing Minor Urologic Procedures

Phase 3 · Terminated · Johns Hopkins University
Recently completed

Effect Of Dexmedetomidine Infusion On Surgical Pleth Index In Pediatrics Undergoing Hypospadias Repair; A Prospective Observational Study

N/A · Completed · Fayoum University Hospital

Does Caudal Block Increase the Incidence of Urethrocutaneous Fistula Formation Following Hypospadias Repair in Infants? A Multi-center Prospective Randomized Trial.

Phase 4 · Completed · University of Colorado, Denver

Does the Single Use of Intravenous Dexamethasone Enhance Analgesic Quality of Pudendal Analgesia in Children Undergoing Hypospadias Surgery?

N/A · Completed · Yonsei University

Comparison of Caudal Block Versus Dexmedetomidine Infusion in Pediatric Patients Undergoing Hypospadias Repair Surgery

N/A · Completed · Tanta University

Isoamyl 2-Cyanoacrylate Interposition in the Urethro-cutaneous Fistula Repair: A Randomized Controlled Trial.

Phase 2/3 · Completed · Ain Shams University

Effect of Intravenous Dexamethasone in Combination With Pudendal Nerve Block on Postoperative Pain Control in Pediatric Hypospadias Repair

Phase 4 · Completed · Dr Sonia ben khalifa (PhD)

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects.

Human reproduction (Oxford, England) · 2001 · 1,444 cites
Recent publications

Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects.

Human reproduction (Oxford, England) · 2001 · 1,444 cites
Major themes1
  • Environmental Exposure1
Leading journals1
  • Human reproduction (Oxford, England)1
Leading researchers3
  • Main KM1
  • Rajpert-De Meyts E1
  • Skakkebaek NE1
Affiliations (unnormalised)1
  • Copenhagen University Hospital1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

A birth defect due to malformation of the URETHRA in which the urethral opening is below its normal location. In the male, the malformed urethra generally opens on the ventral surface of the PENIS or on the PERINEUM. In the female, the malformed urethral opening is in the VAGINA.

Identifiers
MeSHHypospadias
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.