Infarction, Middle Cerebral Artery
Recent clinical, regulatory, research and industry developments relating to this disease.
Brain-Derived Neurotrophic Factor-TrkB Pathway on Synaptic Plasticity in Ischemic Stroke Rats.
Gut Microbiota-Derived Short-Chain Fatty Acids Promote Poststroke Recovery in Aged Mice.
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Clinical trials
The current development programme across all trial phases.
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Major themes8
- Ischemic Stroke3
- Neuroprotective Agents2
- Brain-Derived Neurotrophic Factor1
- Catechin1
- Exosomes1
- Fecal Microbiota Transplantation1
- MicroRNAs1
- Neuronal Plasticity1
Leading journals5
- Aging1
- Circulation research1
- International heart journal1
- Neuroreport1
- PloS one1
Leading researchers8
- Atadja L1
- Bryan RM Jr1
- Chen J1
- d'Aigle J1
- Durgan DJ1
- Fang L1
- Ganesh BP1
- Geng Y1
Affiliations (unnormalised)6
- Alkek Center for Metagenomics and Microbiome Research1
- Baylor College of Medicine1
- Beijing Tiantan Hospital1
- Center for Clinical and Translational Sciences (L.Z.)1
- Changshu Hospital Affiliated to Nanjing University of Chinese Medicine1
- China-Japan Friendship Hospital1
Related conditions
Diseases frequently studied alongside this one. Number shows shared papers.
Disease profile
A grounded synthesis of the condition — overview, causes, mechanism, risk factors and current standard of care.
Middle cerebral artery infarction is a type of cerebral infarction that causes necrosis in the vascular territory supplied by the middle cerebral artery. This territory supplies the lateral aspects of the cerebral hemispheres, so the clinical picture can include impaired cognition, aphasia, agraphia, and weakness or numbness affecting the face and arms.
The disease results from infarction, meaning tissue necrosis, in the middle cerebral artery distribution. The supplied brain regions undergo ischemic injury, and the literature grounding also links the condition with neuronal plasticity as a studied mechanism.
AI-generated summary grounded in MeSH. Informational only — not medical advice. Generated 2026-07-07.
Reference
Authoritative identity, definition & identifiers.
NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.