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Disease

Influenza in Birds

Late-stage therapeutic developmentEmerging research
MeSHInfluenza in Birds
2
Publications
24
Clinical trials
1
Associated genes
2023
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Moderate
Key developments
  • 5 clinical trials expected to report results, the earliest in Q1 2027.
Upcoming Milestones
Major developments
Upcoming trial readoutHigh impact
A Prospective, Multi-national, Multi-center, Open-label, Randomized, Active Controlled, Parallel Group, Operationally Seamless Phase II/III Clinical Study to Evaluate the Immunogenicity, Safety and Lot-to-lot Consistency of LBVD, a Fully Liquid Hexavalent Diphtheria-tetanus-whole Cell Pertussis-hepatitis B-poliovirus (Inactivated)-Haemophilus Influenzae Type b Conjugate (DTwP-HepB-IPV-Hib) Vaccine, Compared to Co-administration of DTwP-HepB-Hib Vaccine and IPV Vaccine in Healthy Infants at 6-, 10-, and 14-week of Age as Primary Series
Results expected Q1 20282026-09-03
Upcoming trial readoutHigh impact
Comparison of Immunogenicity of Different Influenza Vaccines in Patients With Hematologic Malignancies
Results expected Q2 20272026-09-01
Clinical Milestones11View all 11
Results posted 1
Results expected 5
Recently completed 4
Other updates 1
+3 more in the activity timeline below
Activity timeline11

Clinical trials

17 sponsors · 1 new · 4 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
24
All trials
6
Active
16
Late-stage
6
Completed
Late-stage studies

The Dynamics of the Immune Responses to Repeat Influenza Vaccination Exposures (DRIVE III) Study - a Randomized Controlled Trial

Phase 4 · Active, not recruiting · The University of Hong Kong

A Prospective, Multi-national, Multi-center, Open-label, Randomized, Active Controlled, Parallel Group, Operationally Seamless Phase II/III Clinical Study to Evaluate the Immunogenicity, Safety and Lot-to-lot Consistency of LBVD, a Fully Liquid Hexavalent Diphtheria-tetanus-whole Cell Pertussis-hepatitis B-poliovirus (Inactivated)-Haemophilus Influenzae Type b Conjugate (DTwP-HepB-IPV-Hib) Vaccine, Compared to Co-administration of DTwP-HepB-Hib Vaccine and IPV Vaccine in Healthy Infants at 6-, 10-, and 14-week of Age as Primary Series

Phase 2/3 · Active, not recruiting · LG Chem

EVax-3: Human Upper and Lower Airway Mucosal Immune Response to FluMist Vaccination

Phase 4 · Recruiting · Washington University School of Medicine

Comparison of Immunogenicity of Different Influenza Vaccines in Patients With Hematologic Malignancies

Phase 3 · Recruiting · Asan Medical Center

The Effects of Woodsmoke Exposure on Nasal Immune Responses to Influenza Infection in Normal Human Volunteers

Phase 4 · Recruiting · University of North Carolina, Chapel Hill

Immunogenicity and Safety of 2 Doses of Avian Influenza A (H5N1) Vaccine Administered 3 vs. 8 Weeks Apart - A Multi-Center Non-Inferiority Placebo-Controlled Observer-Blinded Phase 2 Randomized Controlled Trial

Phase 4 · Active, not recruiting · Canadian Immunization Research Network
Recently completed

Study of Immune Responses to Influenza Vaccination

Phase 4 · Completed · University of Pennsylvania

A Phase 3/3b, Randomized, Observer-blind, Multicenter Clinical Study to Evaluate the Efficacy, Safety and Immunogenicity of Fluad and Fluad Quadrivalent Compared to a Non-adjuvanted Influenza Vaccine in Adults ≥65 Years of Age

Phase 3 · Completed · Seqirus

A Phase 3, Randomized, Observer-Blind, Active-Control Study to Evaluate the Immunogenicity, Reactogenicity, and Safety of mRNA-1083 (SARS-CoV-2 and Influenza) Vaccine in Healthy Adults ≥50 Years of Age

Phase 3 · Completed · ModernaTX, Inc.

A Multicenter, Randomized, Parallel-group, Double-blind, Comparative Trial of the Superiority of Paracetamol 500mg/Fexofenadine 60mg/Phenylephrine 20mg Fixed-dose Combination Versus Placebo in the Symptomatic Treatment of Flu and Cold

Phase 3 · Completed · Eurofarma Laboratorios S.A.

A Phase 3, Randomized, Observer-blind, Active-controlled, Case-driven Study to Investigate the Safety, Efficacy, and Immunogenicity of mRNA-1010 Candidate Seasonal Influenza Vaccine Compared With a Licensed Inactivated Seasonal Influenza Vaccine in Adults ≥50 Years of Age

Phase 3 · Completed · ModernaTX, Inc.

Randomized Controlled Trial, Double Blind, Phase III, to Evaluate the Immunogenicity of an Adjuvanted Influenza Vaccine Among Health Care Personnel (EDUCATE)

Phase 3 · Completed · Centers for Disease Control and Prevention

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Major themes3
  • Influenza in Birds2
  • Influenza A virus1
  • Influenza A Virus, H9N2 Subtype1
Leading journals2
  • Nature communications1
  • The veterinary quarterly1
Leading researchers8
  • Barclay WS1
  • Bialy D1
  • Brown JC1
  • Campbell C1
  • Goldhill DH1
  • Idoko-Akoh A1
  • Liu X1
  • Long JS1
Affiliations (unnormalised)6
  • Animal Infectious Disease Laboratory1
  • Imperial College London1
  • Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis1
  • Jiangsu Key Laboratory of Zoonosis1
  • National Institute for Biological Standards and Control1
  • Royal Veterinary College1

Associated genes

1 match

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

RNF1510.00

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Infection of domestic and wild fowl and other BIRDS with INFLUENZA A VIRUS. Avian influenza usually does not sicken birds, but can be highly pathogenic and fatal in domestic POULTRY.

Identifiers
MeSHInfluenza in Birds
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.