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Disease
Intracranial Hemorrhages
Late-stage therapeutic developmentEmerging research
2
Publications
12
Clinical trials
2020
Latest publication
Latest activity
betaRecent clinical, regulatory, research and industry developments relating to this disease.
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
Clinical trial2026-09-01Status changed to Completed · ClinicalTrials.gov
What's happening now
An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.
Executive briefingUpdating summary…Momentum: Low
Key developments
- 2 clinical trials expected to report results, the earliest in Q4 2028.
Upcoming Milestones
- Q4 2028The Efficacy and Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients With Recent Ingestion of Factor Xa-inhibitors Trial (SIFT)
- Q2 2029Randomized Comparison of Interventional Closure of the Left Atrial Appendage Using a LAA Closure Device Versus Oral Anticoagulation Therapy in Patients With Non-valvular Atrial Fibrillation and Status Post Intracranial Bleeding.
Major developments
Upcoming trial readoutHigh impact
Results expected Q4 20282026-09-23
Upcoming trial readoutImportant
Results expected Q2 20292026-08-06
Clinical MilestonesViewHide
Results expected
- 2026-09-23The Efficacy and Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients With Recent Ingestion of Factor Xa-inhibitors Trial (SIFT)Results expected Q4 2028
- 2026-08-06Randomized Comparison of Interventional Closure of the Left Atrial Appendage Using a LAA Closure Device Versus Oral Anticoagulation Therapy in Patients With Non-valvular Atrial Fibrillation and Status Post Intracranial Bleeding.Results expected Q2 2029
Recently completed
- 2026-09-30Statins for Treatment Of Primary IntraCerebral Hemorrhage (STOP ICH)Primary completion
Activity timeline3
- 2026-09-30ClinicalStatins for Treatment Of Primary IntraCerebral Hemorrhage (STOP ICH)Primary completion
- 2026-09-23ClinicalThe Efficacy and Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients With Recent Ingestion of Factor Xa-inhibitors Trial (SIFT)Results expected Q4 2028
- 2026-08-06ClinicalRandomized Comparison of Interventional Closure of the Left Atrial Appendage Using a LAA Closure Device Versus Oral Anticoagulation Therapy in Patients With Non-valvular Atrial Fibrillation and Status Post Intracranial Bleeding.Results expected Q2 2029
Clinical trials
The current development programme across all trial phases.
Clinical programme
12
3
7
6
Late-stage studies
Recruiting
Recently completed
Research activity
Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.
Publications over time
Most influential
Major themes2
- Implantable Neurostimulators1
- Quality of Life1
Leading journals2
- Neurology1
- The New England journal of medicine1
Leading researchers8
- Agostini MA1
- Alexopoulos AV1
- Anderson WS1
- Barkley GL1
- Berg MJ1
- Bergey GK1
- Bluhmki E1
- Boggs JG1
Affiliations (unnormalised)2
- From the Cleveland Clinic Foundation (D.R.N.1
- Universität Heidelberg1
Reference
Authoritative identity, definition & identifiers.
Defined in MeSH
Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
Identifiers
References & data sources
- Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
- Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
- Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
- Related entities are derived from literature co-mention (studied together) — associative, not causal.