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Disease

Intracranial Hemorrhages

Late-stage therapeutic developmentEmerging research
MeSHIntracranial Hemorrhages
2
Publications
11
Clinical trials
2020
Latest publication
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2028.
Upcoming Milestones
Major developments
Major clinical milestoneImportant
EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)
Primary completion2026-05-13
Upcoming trial readoutImportant
The Efficacy and Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients With Recent Ingestion of Factor Xa-inhibitors Trial (SIFT)
Results expected Q4 20282025-09-02
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

10 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
11
All trials
3
Active
8
Late-stage
6
Completed
Late-stage studies

EdoxabaN foR IntraCranial Hemorrhage Survivors With Atrial Fibrillation (ENRICH-AF)

Phase 4 · Active, not recruiting · Population Health Research Institute

The Efficacy and Safety of Intravenous Thrombolysis in Acute Ischemic Stroke Patients With Recent Ingestion of Factor Xa-inhibitors Trial (SIFT)

Phase 3 · Recruiting · Guri Hagberg

Fibrinogen Replacement to Prevent Intracranial Haemorrhage in Ischemic Stroke Patients After Thrombolysis: a Pilot Probe Randomized Controlled Trial (FibER)

Phase 3 · Completed · Azienda Usl di Bologna

Start or STop Anticoagulants Randomised Trial (SoSTART) After Spontaneous Intracranial Haemorrhage

Phase 3 · Completed · University of Edinburgh

Prothrombin Complex Concentrate Versus Fresh Frozen Plasma to Correct Coagulation Disorders in Adult Neurosurgical Patients

Phase 4 · Completed · Fondation Ophtalmologique Adolphe de Rothschild

Multicenter, Prospective Randomized Trial on the Use of Prothrombin Complex and Fresh Frozen Plasma in Patients With Intracerebral Hemorrhage Related to Vitamin K Antagonists

Phase 4 · Completed · Heidelberg University
Recently completed

A Phase I Pilot Clinical Trial of TNK Tissue-type Plasminogen Activator (rhTNK-tPA) Dose Escalation for Hypertension-Induced Intracerebral Hemorrhage Using Stereotactic Aspiration Technique to Remove the Hematoma

Phase 1 · Completed · Beijing Tiantan Hospital

Fibrinogen Replacement to Prevent Intracranial Haemorrhage in Ischemic Stroke Patients After Thrombolysis: a Pilot Probe Randomized Controlled Trial (FibER)

Phase 3 · Completed · Azienda Usl di Bologna

A Vanguard, Double-blind, Randomized, Placebo-controlled, Phase 2 Pilot Study to Investigate Prevention of Cardiovascular Events with Oral Colchicine 0.5mg Once Daily Compared with Placebo in Participants with Spontaneous ICH and Established, or Risk Factors For, Atherosclerosis

Phase 2 · Completed · Population Health Research Institute

Start or STop Anticoagulants Randomised Trial (SoSTART) After Spontaneous Intracranial Haemorrhage

Phase 3 · Completed · University of Edinburgh

Prothrombin Complex Concentrate Versus Fresh Frozen Plasma to Correct Coagulation Disorders in Adult Neurosurgical Patients

Phase 4 · Completed · Fondation Ophtalmologique Adolphe de Rothschild

Multicenter, Prospective Randomized Trial on the Use of Prothrombin Complex and Fresh Frozen Plasma in Patients With Intracerebral Hemorrhage Related to Vitamin K Antagonists

Phase 4 · Completed · Heidelberg University

Research activity

2 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Publications over time
20082020
Major themes2
  • Implantable Neurostimulators1
  • Quality of Life1
Leading journals2
  • Neurology1
  • The New England journal of medicine1
Leading researchers8
  • Agostini MA1
  • Alexopoulos AV1
  • Anderson WS1
  • Barkley GL1
  • Berg MJ1
  • Bergey GK1
  • Bluhmki E1
  • Boggs JG1
Affiliations (unnormalised)2
  • From the Cleveland Clinic Foundation (D.R.N.1
  • Universität Heidelberg1

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.

Identifiers
MeSHIntracranial Hemorrhages
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.