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Disease

Joint Diseases

Late-stage therapeutic developmentEmerging research
MeSHJoint Diseases
1
Publications
12
Clinical trials
12
Associated genes
6
Related proteins
2014
Latest publication
Current focus
Ephrin-b2 biologyMucin-4 biologyTherapeutic developmentInflammation & immunity
Latest activity
beta

Recent clinical, regulatory, research and industry developments relating to this disease.

What's happening now

An analyst briefing on current research, clinical, regulatory and industry activity surrounding this disease.

Executive briefingUpdating summary…Momentum: Low
Key developments
  • 1 clinical trial expected to report results, the earliest in Q4 2026.
Upcoming Milestones
Clinical Milestones2View
Results expected 1
Recently completed 1
Activity timeline2

Clinical trials

11 sponsors · 0 new · 0 completed in the last 12 months (net +0)

The current development programme across all trial phases.

Clinical programme
12
All trials
3
Active
7
Late-stage
6
Completed
Late-stage studies

Percutaneous Needle Fasciotomy (PNF) +/- Corticosteroid Injection for Dupuytren's Contracture (DC) Affecting Metacarpophalangeal Joints (MCP) . A Randomized Controlled Trial

Phase 4 · Recruiting · Regionshospitalet Silkeborg

Depot-opioids for Pre- and Postoperative Pain Relief After Primary Knee Arthroplasty. A Double Blinded Randomized Controlled Study. Tapentadol vs Oxycodone vs Placebo

Phase 3 · Completed · St. Olavs Hospital

A Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Arm, Multicenter Study in Subjects With End-Stage Joint Disease to Compare the Frequency of Constipation Symptoms in SubjectsTreated With Tapentadol IR and Oxycodone IR Using a Bowel Function Patient Diary

Phase 3 · Completed · Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol

Phase 4 · Completed · The Methodist Hospital Research Institute

Study of the Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee

Phase 3 · Completed · Bioiberica

Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging.

Phase 4 · Completed · Hvidovre University Hospital
Recently completed

Intraosseous Vancomycin in Primary Total Hip Arthroplasty - Designing a Protocol

Phase 4 · Completed · The Methodist Hospital Research Institute

Depot-opioids for Pre- and Postoperative Pain Relief After Primary Knee Arthroplasty. A Double Blinded Randomized Controlled Study. Tapentadol vs Oxycodone vs Placebo

Phase 3 · Completed · St. Olavs Hospital

Study of the Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee

Phase 3 · Completed · Bioiberica

A Randomized, Double-Blind, Placebo- and Active-Controlled, Parallel-Arm, Multicenter Study in Subjects With End-Stage Joint Disease to Compare the Frequency of Constipation Symptoms in SubjectsTreated With Tapentadol IR and Oxycodone IR Using a Bowel Function Patient Diary

Phase 3 · Completed · Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

Can Bone Erosions Heal in Adalimumab (Humira) Treated Rheumatoid Arthritis Patients. An Imaging Study Using Computed Tomography and Magnetic Resonance Imaging.

Phase 4 · Completed · Hvidovre University Hospital

Fase IV Clinical Trial to Evaluate Chondroitin Sulphate Efficacy and Safety in Patients With Knee Osteoarthritis and Psoriasis

Phase 4 · Completed · Bioiberica

Research activity

1 papers

Key research shaping understanding of this disease, combining the latest publications with the most influential evidence.

Most influential

The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.

Mediators of inflammation · 2014 · 1,112 cites
Recent publications

The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.

Mediators of inflammation · 2014 · 1,112 cites
Leading journals1
  • Mediators of inflammation1
Leading researchers3
  • Poniatowski ŁA1
  • Szukiewicz D1
  • Wojdasiewicz P1
Affiliations (unnormalised)1
  • Medical University of Warsaw1

Associated genes

12 matches

Genes associated with this disease in the canonical knowledge graph (Open Targets evidence). Number shows the association score.

ABCG20.55ANAPC40.52COL27A10.50FOXP10.46LTBP10.44KIF26B0.42SDK10.40RBFOX10.38UQCC10.37HABP20.37SLC2A90.36SLC1A10.36

Disease biology

6 matches

Proteins whose encoding gene is associated with this disease, reached through the canonical gene→disease graph. Number shows the gene's association score.

Ephrin-B2via EFNB20.31Potassium channel subfamily K member 10via KCNK100.28Mucin-4via MUC40.26Scavenger receptor cysteine-rich type 1 protein M130via CD1630.24Interleukin-11via IL110.23Small ribosomal subunit protein eS21via RPS210.17

Reference

Authoritative identity, definition & identifiers.

Defined in MeSH

Diseases involving the JOINTS.

Identifiers
MeSHJoint Diseases
References & data sources
  • Disease identity & definition — NLM Medical Subject Headings (MeSH), public domain
  • Clinical trials — ClinicalTrials.gov (U.S. National Library of Medicine)
  • Research activity — Europe PMC (EMBL-EBI) + OpenAlex-derived paper links
  • Related entities are derived from literature co-mention (studied together) — associative, not causal.